Laboratorio de Investigación en Obesidad y Diabetes, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico.
Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico.
J Leukoc Biol. 2022 Jan;111(1):197-208. doi: 10.1002/JLB.2RU1220-847R. Epub 2021 Mar 16.
Insulin is the hormone responsible for maintaining glucose homeostasis in the body, in addition to participating in lipid metabolism, protein synthesis, and the inhibition of gluconeogenesis. These functions are well characterized in the classic organ target cells that are responsible for general energy regulation: the liver, skeletal muscle, and adipose tissue. However, these actions are not restricted to these tissues because insulin has been shown to affect most cells in the body. This review describes the role of insulin in leukocyte signaling pathways, metabolism and functions, and how insulin resistance could affect this signaling and deteriorate leukocyte metabolism and function, in addition to showing evidence that suggests leukocytes may substantially contribute to the development of systemic insulin resistance.
胰岛素是维持体内葡萄糖稳态的激素，除了参与脂质代谢、蛋白质合成和抑制糖异生外。这些功能在经典的器官靶细胞中得到了很好的描述，这些靶细胞负责一般的能量调节：肝脏、骨骼肌和脂肪组织。然而，这些作用并不局限于这些组织，因为已经证明胰岛素会影响体内大多数细胞。这篇综述描述了胰岛素在白细胞信号通路、代谢和功能中的作用，以及胰岛素抵抗如何影响这种信号转导并恶化白细胞代谢和功能，此外还表明白细胞可能在系统性胰岛素抵抗的发展中起重要作用。
