Turku PET Centre, P.O. Box 52, 20521, Turku, Finland.
Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1141-7. doi: 10.1007/s00259-010-1382-8. Epub 2010 Feb 9.
The aim of this study was to evaluate the visual assessment of positron emission tomography images of N-[methyl-11C]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) in a patient population with mild to moderate memory impairment or dementia.
We compared the visual ratings of two readers using kappa statistics and correlated the results of visual and quantitative region of interest (ROI) analyses. The one reader had good experience in evaluating PIB images and the other had little previous experience. The sensitivity and specificity of the visual assessment was determined using quantitative data from 18 healthy controls previously examined: [11C]PIB uptake was considered as abnormal if it was more than 2 SD above the mean of the healthy subjects.
The evaluation of visual classification as "normal" or "abnormal" showed good interobserver agreement (kappa = 0.90). There was a clear correlation between visual and quantitative analysis (r = 0.47-0.79, p < 0.001). The most difficult visually assessed brain area was the putamen (kappa = 0.11; correlation with quantitative analysis: reader A r = 0.22; reader B r = 0.60).
Our study shows that visual evaluation of [(11)C]PIB images conforms with quantitative analyses also in a clinical patient population supporting the feasibility of visual evaluation in clinical settings.
本研究旨在评估轻度至中度记忆障碍或痴呆患者群体中 N-[甲基-11C]2-(4'-甲基氨基苯基)-6-羟基苯并噻唑([11C]PIB)正电子发射断层扫描(PET)图像的视觉评估。
我们比较了两位读者的视觉评分，使用kappa 统计，并对视觉和定量感兴趣区域(ROI)分析的结果进行了相关性分析。一位读者在评估 PIB 图像方面有丰富的经验，而另一位则经验较少。使用先前检查的 18 名健康对照者的定量数据确定视觉评估的敏感性和特异性：[11C]PIB 摄取被认为异常，如果它超过健康受试者平均值的 2 个标准差以上。
“正常”或“异常”的视觉分类评估显示出良好的观察者间一致性(kappa = 0.90)。视觉和定量分析之间存在明显的相关性(r = 0.47-0.79，p < 0.001)。最难以进行视觉评估的大脑区域是纹状体(kappa = 0.11；与定量分析的相关性：读者 A r = 0.22；读者 B r = 0.60)。
我们的研究表明，[(11)C]PIB 图像的视觉评估与定量分析一致，这也支持了在临床环境中进行视觉评估的可行性。
