相对平衡图改善了图形分析，并允许对定量 11C-PiB PET 研究中的标准化摄取值比进行偏倚校正。
Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies.
机构信息
Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21287-0807, USA.
出版信息
J Nucl Med. 2012 Apr;53(4):622-8. doi: 10.2967/jnumed.111.095927. Epub 2012 Mar 13.
UNLABELLED
Both the standardized uptake value ratio (SUVR) and the Logan plot result in biased distribution volume ratios (DVRs) in ligand-receptor dynamic PET studies. The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET.
METHODS
The overestimation of DVR in SUVR was analyzed theoretically using the Logan and the RE plots. A bias-corrected SUVR (bcSUVR) was derived from the RE plot. Seventy-eight (11)C-PiB dynamic PET scans (66 from controls and 12 from participants with mild cognitive impaired [MCI] from the Baltimore Longitudinal Study of Aging) were acquired over 90 min. Regions of interest (ROIs) were defined on coregistered MR images. Both the ROI and the pixelwise time-activity curves were used to evaluate the estimates of DVR. DVRs obtained using the Logan plot applied to ROI time-activity curves were used as a reference for comparison of DVR estimates.
RESULTS
Results from the theoretic analysis were confirmed by human studies. ROI estimates from the RE plot and the bcSUVR were nearly identical to those from the Logan plot with ROI time-activity curves. In contrast, ROI estimates from DVR images in frontal, temporal, parietal, and cingulate regions and the striatum were underestimated by the Logan plot (controls, 4%-12%; MCI, 9%-16%) and overestimated by the SUVR (controls, 8%-16%; MCI, 16%-24%). This bias was higher in the MCI group than in controls (P < 0.01) but was not present when data were analyzed using either the RE plot or the bcSUVR.
CONCLUSION
The RE plot improves pixelwise quantification of (11)C-PiB dynamic PET, compared with the conventional Logan plot. The bcSUVR results in lower bias and higher consistency of DVR estimates than of SUVR. The RE plot and the bcSUVR are practical quantitative approaches that improve the analysis of (11)C-PiB studies.
未加标签
在配体-受体动态 PET 研究中，标准化摄取值比（SUVR）和 Logan 图都会导致分布容积比（DVR）产生偏差。本研究的目的是使用最近开发的相对平衡图（RE）方法来改进和简化两种常用的 11C-Pittsburgh 化合物 B（11C-PiB）PET 定量方法。
方法
使用 Logan 和 RE 图从理论上分析了 SUVR 中 DVR 的高估。从 RE 图中得出校正后的 SUVR（bcSUV）。对 90 分钟内获得的 78 例（11）C-PiB 动态 PET 扫描（66 例来自对照组，12 例来自巴尔的摩老龄化纵向研究中的轻度认知障碍[MCI]参与者）进行了分析。在配准的磁共振图像上定义了感兴趣区（ROI）。使用 ROI 和像素时间-活性曲线评估了 DVR 的估计值。使用 ROI 时间-活性曲线的 Logan 图获得的 DVR 估计值用作比较 DVR 估计值的参考。
结果
理论分析的结果得到了人体研究的证实。RE 图和 bcSUV 的 ROI 估计值与 ROI 时间-活性曲线的 Logan 图几乎相同。相比之下，使用 Logan 图对 ROI 时间-活性曲线进行分析时，额叶、颞叶、顶叶和扣带回以及纹状体的 ROI 估计值被低估（对照组，4%-12%；MCI，9%-16%），而 SUVR 则被高估（对照组，8%-16%；MCI，16%-24%）。这种偏差在 MCI 组中比对照组更高（P < 0.01），但当使用 RE 图或 bcSUV 进行分析时，这种偏差并不存在。
结论
与传统的 Logan 图相比，RE 图提高了 11C-PiB 动态 PET 的像素定量分析。bcSUV 产生的 DVR 估计值的偏差比 SUVR 更低，一致性更高。RE 图和 bcSUV 是改进 11C-PiB 研究分析的实用定量方法。
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