Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth, Ottawa, Ontario, Canada K1H 8L1.
Cancer. 2010 Mar 15;116(6):1608-14. doi: 10.1002/cncr.24883.
We evaluated 4 different health-related quality of life (HRQL) measures prospectively to determine their ability to detect change over time: the Health Utilities Index Mark 2 and Mark 3, the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core and Cancer Module, the EuroQol EQ-5D visual analogue scale (EuroQol), and the Lansky Play-Performance Scale.
Children with all stages of Hodgkin disease from 12 centers across Canada were asked to complete the 4 measures at 4 time points: 2 weeks after the first course of chemotherapy, on the third day of the second course of chemotherapy, during the third week of radiation, and 1 year after diagnosis.
Fifty-one patients were enrolled in the study between May 1, 2002 and March 31, 2005. Two patients were excluded: 1 patient died shortly after the first time point and the other patient failed to complete any of the questionnaires. All measures showed a significant change between Time 1 and Time 4 (<0.05). When the change in child scores was analyzed between the time points using the child's self-reported change in HRQL, the PedsQL and the EuroQol showed significant change at all time points.
All of the measures were able to detect change in a diverse group of children with Hodgkin disease. The PedsQL and the EuroQol appeared to be the most sensitive to change.
我们前瞻性地评估了 4 种不同的健康相关生活质量（HRQL）测量方法，以确定它们随时间变化检测变化的能力：健康效用指数 Mark 2 和 Mark 3、儿科生活质量问卷（PedsQL）4.0 通用核心和癌症模块、EuroQol EQ-5D 视觉模拟量表（EuroQol）和 Lansky 游戏表现量表。
来自加拿大 12 个中心的各期霍奇金病患儿被要求在 4 个时间点完成 4 项测量：化疗第一疗程后 2 周、第二疗程第 3 天、放疗第 3 周和诊断后 1 年。
2002 年 5 月 1 日至 2005 年 3 月 31 日期间，共有 51 名患者入组该研究。有 2 名患者被排除：1 名患者在第一次测量后不久死亡，另 1 名患者未能完成任何问卷。所有措施在时间 1 和时间 4 之间均显示出显著变化（<0.05）。当使用儿童自我报告的 HRQL 变化分析儿童得分在各时间点之间的变化时，PedsQL 和 EuroQol 在所有时间点均显示出显著变化。
所有措施均能检测出霍奇金病患儿的变化。PedsQL 和 EuroQol 似乎对变化最敏感。
