Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.
Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Oral Dis. 2023 Mar;29(2):747-754. doi: 10.1111/odi.13918. Epub 2021 May 26.
The objective was to describe the reliability and validity of the healthcare professional proxy-report version of the Children's International Mucositis Evaluation Scale (ChIMES).
We included pediatric patients who were between 4 and 21 years of age and scheduled to undergo hematopoietic cell transplantation. Mucositis was evaluated by trained healthcare professionals who scored ChIMES, the World Health Organization oral toxicity scale, mouth, and throat pain visual analogue scale, National Cancer Institute-Common Terminology Criteria and the Oral Mucositis Daily Questionnaire. Measures were completed daily and evaluated on days 7-17 post-stem cell infusion for this analysis. Psychometric properties examined were internal consistency, test-retest reliability (days 13 and 14), and convergent construct validity.
There were 192 participants included. Cronbach's alpha was 0.90 for ChIMES Total Score and 0.93 for ChIMES Percentage Score. Test-retest reliability were as follows: intraclass correlation coefficient (ICC) 0.82 (95% confidence interval (CI) 0.77-0.85) for ChIMES Total Score and ICC 0.82 (95% CI 0.77-0.86) for ChIMES Percentage Score. In terms of construct validation, all correlations between measures met or exceeded those hypothesized (all p < 0.05).
The healthcare professional proxy-report version of ChIMES is reliable and valid for children and adolescents undergoing hematopoietic cell transplantation.
描述儿童国际黏膜炎评价量表（ChIMES）医护人员代理报告版本的信度和效度。
我们纳入了年龄在 4 至 21 岁之间、计划接受造血细胞移植的儿科患者。由经过培训的医护人员评估黏膜炎，采用 ChIMES、世界卫生组织口腔毒性量表、口腔和咽喉疼痛视觉模拟量表、美国国家癌症研究所通用术语标准和口腔黏膜炎每日问卷进行评分。在这项分析中，于干细胞输注后第 7-17 天每天完成测量并进行评估。检查的心理测量学特性包括内部一致性、测试-重测信度（第 13 和 14 天）和收敛结构效度。
共纳入 192 名参与者。ChIMES 总评分和 ChIMES 百分比评分的克朗巴赫系数分别为 0.90 和 0.93。测试-重测信度如下：ChIMES 总评分的组内相关系数（ICC）为 0.82（95%置信区间（CI）为 0.77-0.85），ChIMES 百分比评分的 ICC 为 0.82（95% CI 为 0.77-0.86）。在结构验证方面，所有测量之间的相关性均符合或超过假设值（均 p<0.05）。
用于接受造血细胞移植的儿童和青少年的 ChIMES 医护人员代理报告版本具有可靠性和有效性。
