幽门螺杆菌感染在缺铁性贫血中起作用吗？一项荟萃分析。
Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis.
机构信息
Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China.
出版信息
World J Gastroenterol. 2010 Feb 21;16(7):886-96. doi: 10.3748/wjg.v16.i7.886.
AIM
To perform a meta-analysis of observational studies and randomized controlled trials (RCTs) on the association between Helicobacter pylori (H. pylori) and iron deficiency anemia (IDA).
METHODS
A defined search strategy was used to search Medline, Embase, the Cochrane Library, Clinical Trials, Cochrane Central Register of Controlled Trials, Premedline and Healthstar. Odds ratio (OR) was used to evaluate observational epidemiology studies, and weighted mean difference (WMD) was used to demonstrate the difference between control and intervention groups.
RESULTS
Fifteen observational studies and 5 RCTs were identified and used for calculation. The pooled OR for observational studies was 2.22 (95% CI: 1.52-3.24, P < 0.0001). The WMD for hemoglobin (HB) was 4.06 g/L (95% CI: -2.57-10.69, P = 0.01), and the WMD for serum ferritin (SF) was 9.47 mug/L (95% CI: -0.50-19.43, P < 0.0001). Results were heterogeneous for all comparisons.
CONCLUSION
This meta-analysis on observational studies suggests an association between H. pylori and IDA. In RCTs, eradication of H. pylori can improve HB and SF levels but not significantly.
目的
对幽门螺杆菌（H. pylori）与缺铁性贫血（IDA）之间关联的观察性研究和随机对照试验（RCT）进行荟萃分析。
方法
采用明确的检索策略检索 Medline、Embase、Cochrane 图书馆、临床试验、Cochrane 中心对照试验注册、Premedline 和 Healthstar。使用比值比（OR）评估观察性流行病学研究，使用加权均数差（WMD）来表示对照组和干预组之间的差异。
结果
共确定并使用了 15 项观察性研究和 5 项 RCT 进行计算。观察性研究的合并 OR 为 2.22（95%CI：1.52-3.24，P<0.0001）。血红蛋白（HB）的 WMD 为 4.06g/L（95%CI：-2.57-10.69，P=0.01），血清铁蛋白（SF）的 WMD 为 9.47μg/L（95%CI：-0.50-19.43，P<0.0001）。所有比较结果均存在异质性。
结论
本荟萃分析表明，H. pylori 与 IDA 之间存在关联。在 RCT 中，根除 H. pylori 可以改善 HB 和 SF 水平，但不显著。
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