Wiles F J, Hnizdo E
Epidemiology Research Unit, Johannesburg, South Africa.
Respir Med. 1991 Jan;85(1):27-35. doi: 10.1016/s0954-6111(06)80207-6.
A group of 2,065 gold miners surveyed between 1968 and 1970 was followed to 31 December 1986, at which date 859 were known to be dead. The relationship between airways obstruction and mucus hypersecretion to causes of mortality was analyzed. Airways obstruction was strongly related to mortality from chronic obstructive pulmonary disease (COPD), lung cancer, coronary heart disease and other causes. After standardization for airways obstruction, mucus hypersecretion was not related to mortality from COPD but remained related to mortality from ischaemic heart disease (IDH) and other causes, even after adjustment for tobacco smoking and dust exposure. Mucus hypersecretion was not related to mortality from lung cancer when standardized for airways obstruction.
对1968年至1970年间接受调查的2065名金矿工人进行随访，直至1986年12月31日，已知其中859人死亡。分析了气道阻塞和黏液高分泌与死亡原因之间的关系。气道阻塞与慢性阻塞性肺疾病（COPD）、肺癌、冠心病及其他原因导致的死亡率密切相关。在对气道阻塞进行标准化后，黏液高分泌与COPD导致的死亡率无关，但即使在对吸烟和接触粉尘进行调整后，仍与缺血性心脏病（IDH）及其他原因导致的死亡率相关。当对气道阻塞进行标准化时，黏液高分泌与肺癌导致的死亡率无关。
