National Research Council - Institute for Biological Science, Ottawa, Ontario, K1A 0R6, Canada.
Future Microbiol. 2010 Feb;5(2):267-88. doi: 10.2217/fmb.09.103.
With the comprehensive study and complete sequencing of the Haemophilus influenzae genome in 1995 came the term 'genomics' and the beginning of the 'omics' era. Since this time, several analogous fields, such as transcriptomics and proteomics, have emerged. While growth and advancement in these fields have increased understanding of microbial virulence, the study of bacterial glycomes is still in its infancy and little is known concerning their role in host-pathogen interactions. Bacterial glycomics is challenging owing to the diversity of glyco-conjugate molecules, vast array of unusual sugars and limited number of analytical approaches available. However, recent advances in glycomics technologies offer the potential for exploration and characterization of both the structures and functions of components of bacterial glycomes in a systematic manner. Such characterization is a prerequisite for discerning the role of bacterial glycans in the interaction between host defences and bacterial virulence factors.
随着 1995 年对流感嗜血杆菌基因组的全面研究和完整测序，出现了“基因组学”一词和“组学”时代的开端。从那时起，转录组学和蛋白质组学等几个类似的领域已经出现。尽管这些领域的发展和进步增加了对微生物毒力的理解，但细菌糖组学的研究仍处于起步阶段，对于它们在宿主-病原体相互作用中的作用知之甚少。由于糖缀合物分子的多样性、大量不寻常的糖和可用的分析方法有限，细菌糖组学具有挑战性。然而，糖组学技术的最新进展为系统地探索和表征细菌糖组的结构和功能成分提供了可能。这种表征是辨别细菌聚糖在宿主防御与细菌毒力因子相互作用中的作用的前提。
