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人体中氟化物与维生素D3联合给药后的生物利用度(作者译)

[Biological availability of fluoride after combined administration with vitamin D3 in man (author's transl)].

作者信息

Fuchs C, Dorn D, Grotjahn K, Heimann G, Scheler F

出版信息

Dtsch Med Wochenschr. 1977 Nov 18;102(46):1674-7. doi: 10.1055/s-0028-1105556.

Abstract

Six adults ingested 1 mg fluoride, first as NaF in a watery solution and, secondly, in tablet form (D-Fluoretten 1000). Fluoride concentration was almost identical in the two series. After initial values within the normal range concentrations rapidly rose to a maximum (six times normal) reached on average after 30 minutes, followed by an, at first steep then more gradual, fall in concentration over eight hours. The area under the curve was similar in the two series. These results indicate that the biological availability of fluoride is not influenced by vitamin D3 in the adult and, presumably, in the small child as well.

摘要

六名成年人摄入了1毫克氟化物,首先是以水溶液形式的氟化钠,其次是片剂形式(D-Fluoretten 1000)。两个系列中的氟化物浓度几乎相同。在初始值处于正常范围内后,浓度迅速上升至最大值(正常浓度的六倍),平均在30分钟后达到,随后在八小时内浓度先是急剧下降,然后逐渐下降。两个系列中曲线下面积相似。这些结果表明,氟化物的生物利用度在成年人中不受维生素D3的影响,在幼儿中可能也是如此。

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