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果糖基氨基酸氧化酶工程研究综述:洞察糖化血红蛋白生物传感的未来

Review of fructosyl amino acid oxidase engineering research: a glimpse into the future of hemoglobin A1c biosensing.

作者信息

Ferri Stefano, Kim Seungsu, Tsugawa Wakako, Sode Koji

机构信息

Department of Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

出版信息

J Diabetes Sci Technol. 2009 May 1;3(3):585-92. doi: 10.1177/193229680900300324.

Abstract

Glycated proteins, particularly glycated hemoglobin A1c, are important markers for assessing the effectiveness of diabetes treatment. Convenient and reproducible assay systems based on the enzyme fructosyl amino acid oxidase (FAOD) have become attractive alternatives to conventional detection methods. We review the available FAOD-based assays for measurement of glycated proteins as well as the recent advances and future direction of FAOD research. Future research is expected to lead to the next generation of convenient, simple, and economical sensors for glycated protein, ideally suited for point-of-care treatment and self-monitoring applications.

摘要

糖化蛋白,尤其是糖化血红蛋白A1c,是评估糖尿病治疗效果的重要指标。基于果糖基氨基酸氧化酶(FAOD)的便捷且可重复的检测系统已成为传统检测方法的有吸引力的替代方案。我们综述了现有的基于FAOD的糖化蛋白检测方法以及FAOD研究的最新进展和未来方向。未来的研究有望带来下一代便捷、简单且经济的糖化蛋白传感器,非常适合即时护理治疗和自我监测应用。

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