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使用混合纳米结构材料的用于重要生物医学标志物的电化学传感器的最新趋势。

Recent Trends in Electrochemical Sensors for Vital Biomedical Markers Using Hybrid Nanostructured Materials.

作者信息

Reddy K Koteshwara, Bandal Harshad, Satyanarayana Moru, Goud Kotagiri Yugender, Gobi Kauveri Vengatajalabathy, Jayaramudu Tippabattini, Amalraj John, Kim Hern

机构信息

Smart Living Innovation Technology Centre Department of Energy Science and Technology Myongji University Yongin Gyeonggi-do 17058 Republic of Korea.

Laboratory of Materials Science Instituto de Química de Recursos Naturales Universidad de Talca P.O. Box 747 Talca 3460000 Chile.

出版信息

Adv Sci (Weinh). 2020 May 12;7(13):1902980. doi: 10.1002/advs.201902980. eCollection 2020 Jul.

DOI:10.1002/advs.201902980
PMID:32670744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7341105/
Abstract

This work provides a succinct insight into the recent developments in electrochemical quantification of vital biomedical markers using hybrid metallic composite nanostructures. After a brief introduction to the biomarkers, five types of crucial biomarkers, which require timely and periodical monitoring, are shortlisted, namely, cancer, cardiac, inflammatory, diabetic and renal biomarkers. This review emphasizes the usage and advantages of hybrid nanostructured materials as the recognition matrices toward the detection of vital biomarkers. Different transduction methods (fluorescence, electrophoresis, chemiluminescence, electrochemiluminescence, surface plasmon resonance, surface-enhanced Raman spectroscopy) reported for the biomarkers are discussed comprehensively to present an overview of the current research works. Recent advancements in the electrochemical (amperometric, voltammetric, and impedimetric) sensor systems constructed with metal nanoparticle-derived hybrid composite nanostructures toward the selective detection of chosen vital biomarkers are specifically analyzed. It describes the challenges involved and the strategies reported for the development of selective, sensitive, and disposable electrochemical biosensors with the details of fabrication, functionalization, and applications of hybrid metallic composite nanostructures.

摘要

这项工作简要介绍了使用混合金属复合纳米结构对重要生物医学标志物进行电化学定量分析的最新进展。在对生物标志物进行简要介绍之后，筛选出了五类需要及时和定期监测的关键生物标志物，即癌症、心脏、炎症、糖尿病和肾脏生物标志物。本综述强调了混合纳米结构材料作为识别基质用于检测重要生物标志物的用途和优势。全面讨论了针对生物标志物报道的不同传感方法（荧光、电泳、化学发光、电化学发光、表面等离子体共振、表面增强拉曼光谱），以概述当前的研究工作。特别分析了用金属纳米颗粒衍生的混合复合纳米结构构建的电化学（安培法、伏安法和阻抗法）传感器系统在选择性检测选定的重要生物标志物方面的最新进展。它描述了所涉及的挑战以及为开发具有选择性、灵敏性和一次性的电化学生物传感器所报道的策略，并详细介绍了混合金属复合纳米结构的制备、功能化和应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/d929e4427449/ADVS-7-1902980-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/d929e4427449/ADVS-7-1902980-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/70f452647e7d/ADVS-7-1902980-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/6430f6dd25fe/ADVS-7-1902980-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/6f6d335f8830/ADVS-7-1902980-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/27925016f893/ADVS-7-1902980-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/5e6c1e21b06c/ADVS-7-1902980-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/18fdff8d4343/ADVS-7-1902980-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe4/7341105/d929e4427449/ADVS-7-1902980-g013.jpg

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2
Nanomaterial-based biosensors for detection of pathogenic virus.用于检测致病病毒的基于纳米材料的生物传感器。
Trends Analyt Chem. 2017 Dec;97:445-457. doi: 10.1016/j.trac.2017.10.005. Epub 2017 Oct 13.
3
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4
A Simple and Sensitive Wearable SERS Sensor Utilizing Plasmonic-Active Gold Nanostars.一种利用等离子体活性金纳米星的简单灵敏的可穿戴表面增强拉曼散射传感器。
ACS Omega. 2024 Sep 5;9(37):38897-38905. doi: 10.1021/acsomega.4c05140. eCollection 2024 Sep 17.
5
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