Higgins Trefor, Cembrowski George, Tran David, Lim Erin, Chan Julie
DynaLIFEDx, Edmonton, Alberta, Canada.
J Diabetes Sci Technol. 2009 Jul 1;3(4):644-8. doi: 10.1177/193229680900300404.
Hemoglobin A1c (HbA1c) values are influenced by analytical interferences such as HbF and hemoglobin variants and clinical factors such as increased red cell turnover. Although less well-known, demographic factors such as race, age, and sex also influence HbA1c values. The HbA1c reference range should be homogenous in the United States based on the use of National Glycohemoglobin Standardization Program certified methods and the recommendations in the National Academy of Clinical Biochemistry guidelines.
Data on age, race, sex, HbA1c, and glucose values were extracted from the National Health and Nutrition Examination study for a 3 year period. A search for reference range data for laboratories in the United States was performed using the Google search engine.
Extracted data agree with published data on the influence of age, sex, and smoking status on HbA1c values. There is substantial heterogeneity in HbA1c reference ranges in laboratories in the United States.
Age, sex, and smoking status influence HbA1c values. Despite standardization of HbA1c methods and published recommendations, there is wide heterogeneity in HbA1c reference ranges in the United States.
糖化血红蛋白（HbA1c）值受诸如胎儿血红蛋白（HbF）和血红蛋白变异体等分析干扰因素以及红细胞更新增加等临床因素的影响。虽然种族、年龄和性别等人口统计学因素对HbA1c值的影响鲜为人知，但它们同样会产生影响。基于使用国家糖化血红蛋白标准化计划认证方法以及美国国家临床生物化学学会指南中的建议，美国的HbA1c参考范围应保持一致。
从国家健康与营养检查研究中提取了为期3年的年龄、种族、性别、HbA1c和血糖值数据。使用谷歌搜索引擎搜索了美国各实验室的参考范围数据。
提取的数据与已发表的关于年龄、性别和吸烟状况对HbA1c值影响的数据一致。美国各实验室的HbA1c参考范围存在很大差异。
年龄、性别和吸烟状况会影响HbA1c值。尽管HbA1c检测方法已标准化且有已发表的建议，但美国的HbA1c参考范围仍存在很大差异。
