Galganska Hanna, Karachitos Andonis, Wojtkowska Malgorzata, Stobienia Olgierd, Budzinska Malgorzata, Kmita Hanna
Laboratory of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland.
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1276-80. doi: 10.1016/j.bbabio.2010.02.004. Epub 2010 Feb 6.
Voltage dependent anion channel (VDAC) was identified in 1976 and since that time has been extensively studied. It is well known that VDAC transports metabolites across the outer mitochondrial membrane. The simple transport function is indispensable for proper mitochondria functions and, consequently for cell activity, and makes VDAC crucial for a range of cellular processes including ATP rationing, Ca2+ homeostasis and apoptosis execution. Here, we review recent data obtained for Saccharomyces cerevisiae cells used as a model system concerning the putative role of VDAC in communication between mitochondria and the nucleus. The S. cerevisiae VDAC isoform known as VDAC1 (termed here YVDAC) mediates the cytosol reduction/oxidation (redox) state that contributes to regulation of expression and activity of cellular proteins including proteins that participate in protein import into mitochondria and antioxidant enzymes. Simultaneously, copper-and-zinc-containing superoxide dismutase (CuZnSOD) plays an important role in controlling YVDAC activity and expression levels. Thus, it is proposed that VDAC constitutes an important component of a regulatory mechanism based on the cytosol redox state.
电压依赖性阴离子通道（VDAC）于1976年被发现，自那时起便得到了广泛研究。众所周知，VDAC可跨线粒体外膜转运代谢物。这种简单的转运功能对于线粒体的正常功能乃至细胞活性而言不可或缺，使得VDAC在包括ATP定量、Ca2+稳态及凋亡执行等一系列细胞过程中至关重要。在此，我们综述了以酿酒酵母细胞作为模型系统所获得的有关VDAC在线粒体与细胞核间通讯中假定作用的最新数据。酿酒酵母的VDAC同工型即VDAC1（在此称为YVDAC）介导胞质氧化还原状态，这有助于调节细胞蛋白质的表达及活性，这些蛋白质包括参与蛋白质导入线粒体的蛋白质及抗氧化酶。同时，含铜锌超氧化物歧化酶（CuZnSOD）在控制YVDAC活性及表达水平方面发挥重要作用。因此，有人提出VDAC构成了基于胞质氧化还原状态的调节机制的重要组成部分。
