Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Eur J Pharm Biopharm. 2010 Jun;75(2):200-5. doi: 10.1016/j.ejpb.2010.02.004. Epub 2010 Feb 6.
The ocular structures are very sensitive to damage from ultraviolet (UV) radiation, exposure is linked to corneal and conjunctival damage, cataract formation and may also be implicated in the aetiology of age-related macular degeneration. These structures are usually protected by wearing suitable eyeglasses and goggles. An alternative to conventional eyeglasses/goggles is the concept of "liquid sunglasses" which involve the topical application of eye drops that are designed to block harmful UV radiation reaching the sensitive ocular surfaces. The evaluation of such compounds directly applied to the eye surface requires in situ measurements to compare the efficacy of different formulations. A novel ocular spectrometer system has been used to evaluate changes in the transmission of ultraviolet (UV) radiation through the anterior eye following topical application of candidate UV-absorbing formulations. The key feature of the system is the ability to propagate a beam of light tangentially through the anterior eye using a compact, hand-held lens assembly incorporating UV-transmitting optical fibres. A range of formulations containing UV-absorbing compounds were topically applied to ex vivo rabbit eyes. Significant increases in the absorption of the UV spectrum were detected in seven of the eight formulations studied, demonstrating the potential of this measurement technique in the evaluation of formulations developed as potential topical ocular sunscreens.
眼部结构对紫外线（UV）辐射非常敏感，暴露于紫外线会导致角膜和结膜损伤、白内障形成，并且可能与年龄相关性黄斑变性的病因有关。这些结构通常通过佩戴合适的眼镜和护目镜来保护。传统眼镜/护目镜的替代方案是“液体太阳镜”的概念，它涉及到局部应用旨在阻挡到达敏感眼表面的有害 UV 辐射的眼药水。直接应用于眼表面的此类化合物的评估需要进行原位测量，以比较不同配方的功效。一种新型的眼部分光仪系统已被用于评估在局部应用候选紫外线吸收配方后，通过前眼部的紫外线（UV）辐射传输的变化。该系统的关键特征是使用紧凑的手持式透镜组件和包含紫外透光光纤的能力，使光束沿切线穿过前眼部传播。将含有紫外线吸收化合物的一系列配方局部应用于离体兔眼。在所研究的八种配方中的七种中，均检测到 UV 光谱吸收的显著增加，这证明了该测量技术在评估作为潜在局部眼部防晒霜的配方方面的潜力。
