Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea.
Clin Gastroenterol Hepatol. 2010 May;8(5):443-50.e1-2. doi: 10.1016/j.cgh.2010.02.001. Epub 2010 Feb 6.
BACKGROUND & AIMS: Small studies have shown inconsistent results regarding the association between abdominal visceral adipose tissue and colorectal adenomas. We evaluated the effects of visceral adipose tissue volume on the development and growth of colorectal adenomas.
A total of 3922 participants underwent colonoscopy and computed tomography from February to November 2008. The associations between waist circumference, visceral adipose tissue volume, and colorectal adenomas were estimated with adjusted odds ratios and 95% confidence intervals (CIs). In addition, the association between characteristics of colorectal adenomas and visceral adipose tissue volume was evaluated.
Compared with participants who had visceral adipose tissue volume of less than 500 cm(3), the odds ratio for colorectal adenoma was 1.09 (95% CI, 0.87-1.36) for a volume of 500 to 999 cm(3), 1.33 (95% CI, 1.04-1.69) for a volume of 1000 to 1499 cm(3), and 1.43 (95% CI, 1.06-1.94) for a volume of 1500 cm(3) or greater. The risk of colorectal adenomas increased with increasing visceral adipose tissue volume in both sexes (P trend = .004 in men and .009 in women). Waist circumference was associated with colorectal adenomas in men (P trend = .02), but not in women. High volume of visceral adipose tissue (>or=1000 cm(3)) had a positive association with larger adenomas (>or=10 mm) and multiple adenomas.
Abdominal visceral adipose tissue volume can contribute to the development and growth of colorectal adenomas, and it was a better predictor for risk of colorectal adenomas than body mass index or waist circumference in both sexes.
一些小型研究表明，腹部内脏脂肪组织与结直肠腺瘤之间的关联结果并不一致。我们评估了内脏脂肪组织体积对结直肠腺瘤发生和生长的影响。
共有 3922 名参与者于 2008 年 2 月至 11 月间接受了结肠镜检查和计算机断层扫描。采用校正优势比及其 95%置信区间（CI）评估腰围、内脏脂肪组织体积与结直肠腺瘤之间的关联。此外，还评估了结直肠腺瘤特征与内脏脂肪组织体积之间的关联。
与内脏脂肪组织体积<500 cm(3)的参与者相比，体积为 500999 cm(3)、10001499 cm(3)和 1500 cm(3)或更大的参与者发生结直肠腺瘤的优势比（OR）分别为 1.09（95%CI，0.871.36）、1.33（95%CI，1.041.69）和 1.43（95%CI，1.06~1.94）。在男性和女性中，随着内脏脂肪组织体积的增加，结直肠腺瘤的风险均升高（男性 P 趋势=0.004，女性 P 趋势=0.009）。腰围与男性结直肠腺瘤相关（P 趋势=0.02），但与女性无关。高内脏脂肪组织体积（>或=1000 cm(3)）与较大腺瘤（>或=10 mm）和多发性腺瘤呈正相关。
腹部内脏脂肪组织体积可能有助于结直肠腺瘤的发生和生长，其对男性和女性结直肠腺瘤风险的预测作用优于体重指数或腰围。
