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脂质代谢作为结直肠癌中一个可靶向的代谢弱点

Lipid Metabolism as a Targetable Metabolic Vulnerability in Colorectal Cancer.

作者信息

Zaytseva Yekaterina

机构信息

Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305, USA.

出版信息

Cancers (Basel). 2021 Jan 15;13(2):301. doi: 10.3390/cancers13020301.

DOI:10.3390/cancers13020301
PMID:33467532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7830794/
Abstract

Colorectal cancer (CRC), the second leading cause of cancer-related deaths according to the World Health Organization, remains a substantial public health problem worldwide [...].

摘要

根据世界卫生组织的数据，结直肠癌（CRC）是癌症相关死亡的第二大主要原因，在全球范围内仍然是一个严重的公共卫生问题[……]

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本文引用的文献

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FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport.脂肪酸结合蛋白4通过调节脂肪酸转运促进结肠癌的侵袭和转移。
Cancer Cell Int. 2020 Oct 19;20:512. doi: 10.1186/s12935-020-01582-4. eCollection 2020.
2
Obesity Has a Stronger Relationship with Colorectal Cancer in Postmenopausal Women than Premenopausal Women.与绝经前女性相比，肥胖与绝经后女性的结直肠癌关系更为密切。
Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2277-2288. doi: 10.1158/1055-9965.EPI-20-0594. Epub 2020 Aug 31.
3
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells.脂肪酸合酶的抑制上调CD36的表达以维持结肠癌细胞的增殖。
Front Oncol. 2020 Jul 31;10:1185. doi: 10.3389/fonc.2020.01185. eCollection 2020.
4
Rising Incidence of Colorectal Cancer in Young Adults Corresponds With Increasing Surgical Resections in Obese Patients.年轻人结直肠癌发病率上升与肥胖患者手术切除量增加有关。
Clin Transl Gastroenterol. 2020 Apr;11(4):e00160. doi: 10.14309/ctg.0000000000000160.
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Lipid droplets: platforms with multiple functions in cancer hallmarks.脂滴：癌症标志中具有多种功能的平台。
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Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples.磷脂谱分析可用于区分肿瘤和非肿瘤来源的人结肠上皮细胞：结肠癌细胞系和患者来源的细胞样本中的磷脂组学相似性和差异。
PLoS One. 2020 Jan 30;15(1):e0228010. doi: 10.1371/journal.pone.0228010. eCollection 2020.
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Reprogramming of fatty acid metabolism in cancer.癌症中脂肪酸代谢的重编程。
Br J Cancer. 2020 Jan;122(1):4-22. doi: 10.1038/s41416-019-0650-z. Epub 2019 Dec 10.
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