Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany.
Curr Opin Immunol. 2010 Apr;22(2):161-7. doi: 10.1016/j.coi.2010.01.010. Epub 2010 Feb 9.
Differentiation of B lymphocytes involves the step-wise acquisition of a specialized phenotype that depends on the expression of lineage-specific genes and the repression of genes characteristic of multipotent progenitors and alternate lineages. The early steps of B lineage specification and commitment are, partly, controlled by the well-characterized transcription factors Ikaros, Pu.1, E2A, early B cell factor-1, and Pax5 that act in a complex regulatory network. However, our understanding of B cell differentiation is far from complete. Recent work has shed light on the mechanisms by which transcription factors implement cell type-specific gene expression patterns and epigenetic changes in chromatin that allow for B lineage specification and commitment.
B 淋巴细胞的分化涉及逐步获得专门表型，这取决于谱系特异性基因的表达和多能祖细胞和其他谱系特征基因的抑制。B 谱系特化和承诺的早期步骤部分受特征明确的转录因子 Ikaros、Pu.1、E2A、早期 B 细胞因子-1 和 Pax5 的控制，这些转录因子在复杂的调控网络中发挥作用。然而，我们对 B 细胞分化的理解还远远不够。最近的工作揭示了转录因子如何实现细胞类型特异性基因表达模式和染色质中的表观遗传变化的机制，这些变化允许 B 谱系特化和承诺。
