Department of Immunology, Lund University, Lund, Sweden.
Curr Opin Immunol. 2010 Apr;22(2):148-53. doi: 10.1016/j.coi.2010.02.001. Epub 2010 Mar 6.
Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or B220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.
尽管从造血干细胞中分化出 B 淋巴细胞是研究最深入的成体细胞分化模型之一，但最近的一系列发现在很大程度上加深了我们对 B 淋巴细胞分化的理解。这些发现包括鉴定出 IKAROS、PU.1 和 E2A 作为多能细胞中负责淋巴谱系定型的转录因子，以及鉴定出 EBF1 依赖性 B 谱系限制祖细胞，这些细胞缺乏经典 B 谱系标志物 CD19 或 B220 的表达。这一见解表明，B 细胞的特性可能比以前认为的更早确定，这使得我们能够更好地理解 B 淋巴细胞的发育，可能会揭示与造血系统内外其他分化过程相关的重要分子机制。
