WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia, Penang, Malaysia.
Hum Exp Toxicol. 2010 Sep;29(9):773-8. doi: 10.1177/0960327110361759. Epub 2010 Feb 9.
Hypokalemia is not an isolated disease but an associated finding in a number of different diseases. It is also a commonly neglected condition among patients with acute acetaminophen overdose.
This study intended to determine the prevalence of hypokalemia and its clinical correlates in acute psychiatric illness among hypokalemic and normokalemic patients after acetaminophen overdose.
This is a retrospective cohort study of hospital admissions for acute acetaminophen overdose conducted over a period of 5 years from 1 January 2004 to 31 December 2008. Demographic data and different types of psychiatric illness were compared between hypokalemic and normokalemic patients. Hypokalemia was predefined by a serum concentration <3.5 mmol/L. Statistical Package for Social Sciences (SPSS) 15 was used for data analysis.
Two hundred and eighty patients out of 305 admissions were studied. Hypokalemia was found in 63.6% of patients with a higher prevalence in the presence of psychiatric illness (67.7%). Hypokalemic patients were significantly associated with the presence of major depression (p = .04), adjustment disorder (p < .001), anxiety (p = .01), and suicidal attempts (p = .04).
Hypokalemia was common among patients with psychiatric illness and acute acetaminophen overdose.
低钾血症并不是一种孤立的疾病，而是许多不同疾病的相关表现。它也是急性乙酰氨基酚过量患者中经常被忽视的一种病症。
本研究旨在确定低钾血症在急性精神病患者中的流行率及其与乙酰氨基酚过量后低钾血症和正常血钾血症患者的临床相关性。
这是一项回顾性队列研究，对 2004 年 1 月 1 日至 2008 年 12 月 31 日期间的急性乙酰氨基酚过量住院患者进行了为期 5 年的研究。比较低钾血症和正常血钾血症患者的人口统计学数据和不同类型的精神病。低钾血症定义为血清浓度<3.5mmol/L。使用社会科学统计软件包（SPSS）15 进行数据分析。
在 305 例住院患者中，有 280 例患者进行了研究。63.6%的患者存在低钾血症，而在存在精神疾病的情况下，低钾血症的患病率更高（67.7%）。低钾血症患者与重度抑郁症（p=0.04）、适应障碍（p<0.001）、焦虑症（p=0.01）和自杀企图（p=0.04）显著相关。
低钾血症在急性乙酰氨基酚过量合并精神病患者中较为常见。
