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间质干细胞的免疫抑制能力:胰岛移植中的治疗意义。

Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantation.

机构信息

Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

出版信息

Transplantation. 2010 Feb 15;89(3):270-3. doi: 10.1097/TP.0b013e3181c6ffbe.

Abstract

Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses and offer therapeutic potential for achieving transplantation tolerance. This review will discuss the impacts of MSCs on transplant immunity and focus on the potential role of MSCs in protecting islet grafts from both rejection and autoimmune attack.

摘要

间充质干细胞(MSCs)被认为具有抑制免疫反应的能力,并为实现移植耐受提供了治疗潜力。本综述将讨论 MSCs 对移植免疫的影响,并重点探讨 MSCs 在保护胰岛移植物免受排斥和自身免疫攻击方面的潜在作用。

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