Akanyibah Francis Atim, He Chang'e, Cai Peipei, Wang Xiu, Wang Ying, Mao Fei
Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Institute of Hematology, Jiangsu University, Zhenjiang, Jiangsu, China.
Front Immunol. 2025 Jun 4;16:1597462. doi: 10.3389/fimmu.2025.1597462. eCollection 2025.
The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, are influenced by the immune system, environmental factors, genetics, and intestinal flora. Cell death is a biological phenomenon that occurs in all living organisms; nevertheless, excessive cell death has been linked to IBD, including increased immune and intestinal epithelial cell death and intestinal barrier abnormalities. Anti-tumor necrosis factor medication, which has made significant progress in treating IBD cell death, may fail in some individuals or lose effectiveness over time, necessitating the search for a safe and effective treatment. One of the novel and emerging areas in regenerative and nanomedicine used to regulate cell death is mesenchymal stem cells (MSCs) and their mediators (extracellular vesicles). MSCs and their mediators have been found to attenuate cell death in several illnesses, including IBD. This review explores cell death mechanisms and their implications in IBD, focusing on the potential ameliorative effects of MSCs and their mediators on cell death.
炎症性肠病（IBD）包括溃疡性结肠炎和克罗恩病，其发病和进展受免疫系统、环境因素、遗传学和肠道菌群影响。细胞死亡是所有生物体都会发生的一种生物学现象；然而，过度细胞死亡与IBD有关，包括免疫细胞和肠道上皮细胞死亡增加以及肠道屏障异常。抗肿瘤坏死因子药物在治疗IBD细胞死亡方面取得了重大进展，但在某些个体中可能无效或随着时间推移失去效力，因此需要寻找一种安全有效的治疗方法。用于调节细胞死亡的再生医学和纳米医学中一个新兴领域是间充质干细胞（MSC）及其介质（细胞外囊泡）。已发现MSC及其介质可减轻包括IBD在内的多种疾病中的细胞死亡。本综述探讨细胞死亡机制及其在IBD中的影响，重点关注MSC及其介质对细胞死亡的潜在改善作用。
