Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan.
Eye Contact Lens. 2010 Mar;36(2):86-9. doi: 10.1097/ICL.0b013e3181d13a90.
To determine whether Aphex KC, a newly designed rigid gas-permeable (RGP) contact lens with dual aspherical base curves, improves visual acuity and lens wear time in patients with keratoconus.
We performed a retrospective analysis of a noncomparative case series of 29 eyes of 24 patients with keratoconus who were intolerant of spherical RGP contact lenses and were fitted with Aphex KC at Yamaguchi University Hospital. Visual acuity and lens wear time were recorded as primary outcome measures at follow-up visits. Six patients with a follow-up period of <1 year were excluded from data analysis. At the last follow-up visit, 86.2% of eyes (25 eyes of 20 patients) continued to wear Aphex KC.
Mean uncorrected visual acuity was 1.4 LogMAR (20/500 in Snellen notation) for the 29 eyes enrolled in the study. Mean best-corrected visual acuity was 0.1 LogMAR (20/25) with Aphex KC and 0.7 LogMAR (20/111) with glasses (P < 0.001). A total of 19 eyes (65.5%) had a best-corrected visual acuity of 0.2 LogMAR (20/29) or better with Aphex KC. The mean +/- SD wear time was 12.6 +/- 3.2 hr/day with Aphex KC and 0.4 +/- 0.7 hr/day with a previously prescribed spherical RGP contact lens (P = 1 x 10). The numbers of eyes wearing Aphex KC or the previously prescribed RGP contact lens for >12 hr/day were 26 and 0, respectively (P = 1 x 10). No serious complications of Aphex KC wear were observed.
Fitting of an Aphex KC lens improved visual acuity and increased lens wear time in keratoconus patients who were intolerant of a spherical RGP contact lens. Aphex KC thus provides a viable alternative for management of such patients.
确定 Aphex KC,一种新设计的双非球面基弧硬性透气性 (RGP) 隐形眼镜,是否能提高圆锥角膜患者的视力和隐形眼镜佩戴时间。
我们对山口大学医院的 24 名圆锥角膜患者的 29 只眼睛进行了回顾性非对照病例系列分析,这些患者对球面 RGP 隐形眼镜不耐受,并佩戴了 Aphex KC。在随访时,视力和隐形眼镜佩戴时间被记录为主要观察指标。由于随访时间<1 年,有 6 名患者的数据被排除在分析之外。在最后一次随访时,86.2%的眼睛(20 名患者中的 25 只眼睛)继续佩戴 Aphex KC。
研究中纳入的 29 只眼睛的平均未矫正视力为 1.4 LogMAR(Snellen 记分为 20/500)。使用 Aphex KC 的平均最佳矫正视力为 0.1 LogMAR(20/25),而使用眼镜的平均最佳矫正视力为 0.7 LogMAR(20/111)(P<0.001)。使用 Aphex KC,19 只眼睛(65.5%)的最佳矫正视力达到 0.2 LogMAR(20/29)或更好。使用 Aphex KC 的平均佩戴时间为 12.6 +/- 3.2 小时/天,而使用之前规定的球面 RGP 隐形眼镜的平均佩戴时间为 0.4 +/- 0.7 小时/天(P=1 x 10)。佩戴 Aphex KC 或之前规定的 RGP 隐形眼镜超过 12 小时/天的眼睛数量分别为 26 只和 0 只(P=1 x 10)。没有观察到 Aphex KC 佩戴的严重并发症。
对于不能耐受球面 RGP 隐形眼镜的圆锥角膜患者,Aphex KC 隐形眼镜的佩戴改善了视力,并增加了隐形眼镜佩戴时间。因此,Aphex KC 为这些患者的治疗提供了一种可行的选择。