Westrich Geoffrey, Schaefer Sarah, Walcott-Sapp Sarah, Lyman Stephen
Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA.
Am J Orthop (Belle Mead NJ). 2009 Dec;38(12):612-6.
Intra-articular injections of hyaluronic acid products may eliminate pain, improve mobility and quality of life, and delay osteoarthritis progression. In this study, we evaluated the safety and efficacy of sodium hyaluronate injections given after knee arthroscopy. Forty-six patients with early osteoarthritis and a symptomatic meniscus tear were prospectively randomized into study (injection) and control groups and underwent knee arthroscopy. Study patients received 3 sodium hyaluronate injections after surgery. Study and control outcomes were compared 3 and 6 months after surgery. The injection patients had significantly less pain (visual analog scale) at 3-month follow-up and more flexion at 6-month follow-up. Tenderness, pain on motion, and crepitus were significantly more likely to be absent from injection patients at the 3- and 6-month follow-ups. Patients with osteoarthritis and a symptomatic meniscus tear may experience more pain relief and functional mobility after arthroscopic surgery plus hyaluronic acid injections than after arthroscopy alone.
关节内注射透明质酸产品可消除疼痛、改善活动能力和生活质量，并延缓骨关节炎的进展。在本研究中，我们评估了膝关节镜检查后注射透明质酸钠的安全性和有效性。46例早期骨关节炎伴症状性半月板撕裂患者被前瞻性随机分为研究组（注射组）和对照组，并接受了膝关节镜检查。研究组患者术后接受3次透明质酸钠注射。在术后3个月和6个月比较研究组和对照组的结果。注射组患者在3个月随访时疼痛明显减轻（视觉模拟评分），在6个月随访时屈曲度增加。在3个月和6个月随访时，注射组患者压痛、活动时疼痛和摩擦音明显更不易出现。与单纯关节镜检查相比，骨关节炎伴症状性半月板撕裂患者在关节镜手术加透明质酸注射后可能会获得更多的疼痛缓解和功能活动能力。
