The Queen's University of Belfast, QUILL, School of Chemistry and Chemical Engineering, Belfast, Northern Ireland BT9 5AG.
Phys Chem Chem Phys. 2010 Feb 28;12(8):2011-7. doi: 10.1039/b923855g. Epub 2010 Jan 22.
We present an ionic liquid (IL) approach towards a dual functional liquid salt form of aspirin using different pharmaceutically active cations composed of antibacterials, analgesics, local anesthetics, and antiarrhythmic drugs in combination with acetylsalicylic acid or its metabolite salicylic acid and discuss stability of these ILs in comparison to solid salts. Several low-melting or liquid salts of salicylic acid with dual functionality and promising properties were isolated and characterized; however, although such ILs with aspirin could be prepared, they suffer from limited stability and slowly decompose into the corresponding salicylate ILs when exposed to moisture.
我们提出了一种使用不同药用活性阳离子的离子液体（IL）方法，将阿司匹林制成具有双重功能的液体盐形式，这些阳离子由抗菌剂、镇痛药、局部麻醉剂和抗心律失常药物与乙酰水杨酸或其代谢物水杨酸组成，并讨论了这些 IL 与固体盐相比的稳定性。分离和表征了几种具有双重功能和有前途性质的水杨酸低熔点或液体盐；然而，尽管可以制备具有阿司匹林的此类 IL，但它们的稳定性有限，当暴露于水分时会缓慢分解为相应的水杨酸盐 IL。
