Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria.
Chem Commun (Camb). 2011 Feb 28;47(8):2267-9. doi: 10.1039/c0cc04485g. Epub 2010 Dec 16.
We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid-base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.
我们提出了证据，证明氢键的形成而非盐的形成是中性酸碱配合物形式的固体药物液化的驱动力，局部麻醉药利多卡因与脂肪酸混合物形成的液体就是一个例子；这些配合物存在于简单共晶和部分离解的离子液体之间的边界。
