Departments of Neurosciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy.
J Neurooncol. 2010 Sep;99(2):287-8. doi: 10.1007/s11060-010-0130-z. Epub 2010 Feb 10.
Thymoma-associated paraneoplastic diseases include myasthenia gravis (MG), neuromyotonia (NMT), Morvan's syndrome, and several non-neurological paraneoplastic manifestations, including glomerulonephritis. Paraneoplastic syndromes often precede the occurrence of thymoma, but cases occurring after thymomectomy, which sometimes herald the recurrence of thymoma, have also been described. We report on a patient who developed MG after thymomectomy for a malignant thymoma. After MG remission, NMT and Morvan's syndrome occurred, which heralded a mediastinic recurrence, as demonstrated only by autopsy findings.
胸腺瘤相关的副肿瘤疾病包括重症肌无力（MG）、肌强直（NMT）、莫旺综合征和几种非神经副肿瘤表现，包括肾小球肾炎。副肿瘤综合征通常先于胸腺瘤发生，但也有术后发生的病例，有时预示着胸腺瘤的复发。我们报告了一例恶性胸腺瘤切除术后发生 MG 的患者。MG 缓解后，出现 NMT 和莫旺综合征，提示纵隔复发，仅通过尸检结果证实。
