Evoli A, Lo Monaco M, Marra R, Lino M M, Batocchi A P, Tonali P A
Institute of Neurology and Hematology, Catholic University, Roma, Italy.
Neuromuscul Disord. 1999 Dec;9(8):601-3. doi: 10.1016/s0960-8966(99)00046-2.
Here we report a patient with a lymphoepithelial thymoma who developed in chronological sequence limbic encephalitis, neuromyotonia and myasthenia gravis. The patient presented with limbic encephalitis associated with an invasive thymoma and improved after surgery and cytotoxic therapy. Two months after thymectomy, neuromyotonia associated with hyperhidrosis and mild motor neuropathy occurred and the patient was given plasma-exchange and prednisone therapy. Five months later he developed mild generalised myasthenia gravis. Anti-acetylcholine receptor antibodies, previously repeatedly negative, were found positive at the onset of clinical signs of myasthenia gravis.
在此，我们报告一例患有淋巴上皮性胸腺瘤的患者，该患者按时间顺序先后出现边缘叶脑炎、神经性肌强直和重症肌无力。患者表现为与侵袭性胸腺瘤相关的边缘叶脑炎，手术及细胞毒性治疗后病情改善。胸腺切除术后两个月，出现与多汗症及轻度运动神经病相关的神经性肌强直，患者接受了血浆置换及泼尼松治疗。五个月后，他出现轻度全身性重症肌无力。抗乙酰胆碱受体抗体此前多次检测为阴性，在重症肌无力临床症状出现时呈阳性。
