Camuto P, Schinella R, Gilchrist K, Citrin D, Fredrickson G
Department of Pathology, New York University Medical Center, New York.
Urology. 1991 Apr;37(4):380-4. doi: 10.1016/0090-4295(91)80273-a.
Flow cytometric studies of archival material from 22 adrenal carcinomas demonstrated aneuploidy in 21 of 22 cases. Heterogeneity of nuclear DNA was found in 14 of the 22 cases. Eight of these showed distinct aneuploid and diploid populations, and 6 showed multiple aneuploid cell lines. The heterogeneity was detected because numerous paraffin-embedded samples of each tumor could be examined. No correlation was found between either aneuploidy or heterogeneous DNA content and patient survival, response to therapy, or hormone secretion.
对22例肾上腺癌存档材料进行的流式细胞术研究表明，22例中有21例存在非整倍体。22例中有14例发现核DNA存在异质性。其中8例显示出明显的非整倍体和二倍体细胞群，6例显示出多个非整倍体细胞系。之所以能检测到这种异质性，是因为可以检查每个肿瘤的大量石蜡包埋样本。未发现非整倍体或异质DNA含量与患者生存率、对治疗的反应或激素分泌之间存在相关性。
