Savitskiĭ G A
Vopr Onkol. 1991;37(2):179-84.
The study of local blood flow in the uterus in 100 cases of uterine fibromyoma established increased blood levels of estradiol and progesteron. Blood estradiol level in the local flow of the uterus was relatively high in postmenopausal women, particularly, in those suffering uterine myoma. "Foreign" estradiol-dependent tissue substrates such as myoma and hyperplastic lesions of the endometrium were found to be responsible for potentiating local transfer and thus raising local concentration of ovarian hormones. Regulation of subovarian transfer and accumulation of hormones was shown to be to a large extent independent of levels of basic sex steroids in the general blood flow of the female body. Chronic local hyperestradiolemia in the uterus is the key factor for hyperplastic lesions development in the endometrium.
对100例子宫肌瘤患者子宫局部血流的研究证实，雌二醇和孕酮的血液水平升高。绝经后女性子宫局部血流中的血液雌二醇水平相对较高，尤其是患有子宫肌瘤的女性。发现诸如肌瘤和子宫内膜增生性病变等“外源性”依赖雌二醇的组织底物可增强局部转运，从而提高卵巢激素的局部浓度。研究表明，卵巢下激素的转运和积累在很大程度上独立于女性身体总体血流中基本性类固醇的水平。子宫内慢性局部高雌二醇血症是子宫内膜增生性病变发展的关键因素。
