Saano V, Nuutinen J, Virta P, Joki S, Karttunen P, Silvasti M
Department of Pharmacology, University of Kuopio, Finland.
Acta Otolaryngol. 1991;111(1):130-4.
The effect of adenosine triphosphate (ATP) on the airway ciliary beating frequency (CBF) of mucosal explants excised from human maxillary sinuses was studied by measuring CBF photoelectrically before and after immersion of the explants in a solution containing ATP. In samples from 64 patients with chronic sinusitis the CBF was not significantly different from the CBF in mucosal specimens from healthy tissue of 22 patients without infection. During 15 min immersion, ATP (1 mg/ml) slightly (by 5%, p less than 0.05 in healthy tissue; by 2.7%, p less than 0.01, in tissue from sinusitis patients) increased the CBF. The effect of 10 mg/ml concentration was more pronounced (19.6%). It is concluded that the impairment in ciliary function caused by chronic sinusitis is reversible when the mucosal endothelium is cleansed of the infected mucus, and that the ciliostimulatory action of ATP seen in animals is also present in human respiratory mucosa.
通过在含有三磷酸腺苷（ATP）的溶液中浸泡前后光电测量从人上颌窦切除的黏膜外植体的气道纤毛摆动频率（CBF），研究了ATP对其的影响。在64例慢性鼻窦炎患者的样本中，CBF与22例无感染的健康组织黏膜标本中的CBF无显著差异。在浸泡15分钟期间，ATP（1毫克/毫升）使CBF略有增加（健康组织中增加5%，p<0.05；鼻窦炎患者组织中增加2.7%，p<0.01）。10毫克/毫升浓度的效果更明显（增加19.6%）。得出的结论是，当黏膜内皮清除感染性黏液时，慢性鼻窦炎引起的纤毛功能损害是可逆的，并且在动物中观察到的ATP的纤毛刺激作用在人呼吸道黏膜中也存在。
