Braverman I, Wright E D, Wang C G, Eidelman D, Frenkiel S
Department of Otolaryngology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec.
J Otolaryngol. 1998 Jun;27(3):145-52.
Ciliary-beat frequency (CBF) is an important factor influencing mucociliary flow in the respiratory tract. A significant correlation exists between CBF and mucus transport time (MTT), which suggests that CBF is the main factor in nasal mucociliary clearance in healthy individuals. Mucociliary clearance is influenced by the temperature of the inspired air and decreases at temperatures below 33 degrees C. It is unknown whether CBF varies in different sites within the nasal chamber and exactly how CBF is altered in disease states such as chronic sinusitis (CS) and nasal polyposis (NP). Our study was conducted in an attempt to answer these questions.
CBF was measured in nasal biopsies from eight normal control subjects: 6 CS and 8 NP patients. Biopsies from the regions of the maxillary, ethmoid, frontal, and sphenoid sinus ostia were also obtained. The material was analyzed using a computerized image-processing system.
Our data demonstrated a significant decrease in CBF at 22 degrees C compared to at 35 degrees C for all sinus biopsies (p < .05). We found no statistical difference between the CBF of biopsies from the regions of the various sinus ostia. A comparison between the patients with CS and normal controls again revealed no significant difference in CBF, a finding which contradicts previously published reports. Surprisingly, an increase in CBF was observed in NP patients compared to control and CS patients (p < .05).
We conclude that our technique is a viable model for studying sinonasal CBF in the human. Our data suggest that a mechanism other than decreased CBF may account for the decreased mucociliary clearance observed in chronic sinusitis.
纤毛摆动频率（CBF）是影响呼吸道黏液纤毛运输的一个重要因素。CBF与黏液运输时间（MTT）之间存在显著相关性，这表明CBF是健康个体鼻腔黏液纤毛清除的主要因素。黏液纤毛清除受吸入空气温度的影响，在温度低于33摄氏度时会降低。目前尚不清楚CBF在鼻腔内不同部位是否存在差异，以及在慢性鼻窦炎（CS）和鼻息肉（NP）等疾病状态下CBF究竟是如何改变的。我们开展这项研究旨在回答这些问题。
对8名正常对照受试者、6名CS患者和8名NP患者的鼻活检组织进行CBF测量。还获取了上颌窦、筛窦、额窦和蝶窦开口区域的活检组织。使用计算机图像处理系统对材料进行分析。
我们的数据表明，与35摄氏度时相比，所有鼻窦活检组织在22摄氏度时的CBF均显著降低（p < 0.05）。我们发现不同鼻窦开口区域活检组织的CBF之间无统计学差异。CS患者与正常对照之间的比较再次显示CBF无显著差异，这一发现与先前发表的报告相矛盾。令人惊讶的是，与对照和CS患者相比，NP患者的CBF有所增加（p < 0.05）。
我们得出结论，我们的技术是研究人类鼻窦CBF的一种可行模型。我们的数据表明，除了CBF降低之外，可能还有其他机制导致慢性鼻窦炎中观察到的黏液纤毛清除减少。
