University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Thorax. 2010 Feb;65(2):181-6. doi: 10.1136/thx.2008.112896.
Sarcoidosis of the upper respiratory tract (SURT) includes nasopharyngeal, laryngeal and tracheal disease. Documented SURT occurs in approximately 5% of patients, although upper airway symptoms are more common in patients with sarcoidosis. Wegener granulomatosis may have a similar appearance to SURT, but there are important differences in the manifestations of the disease locally as well as systemically. In some cases, topical treatment is adequate to control SURT. However, many patients with significant sinus or laryngeal disease require long-term systemic treatment. While corticosteroids are often the initial drug of choice, there have been several reports of the effectiveness of cytotoxic agents and anti-tumour necrosis factor antibodies.
上呼吸道结节病（SURT）包括鼻咽、喉和气管疾病。据报道，SURT 约发生于 5%的患者中，尽管气道症状在上呼吸道疾病患者中更为常见。韦格纳肉芽肿可能与 SURT 表现相似，但局部和全身表现存在重要差异。在某些情况下，局部治疗即可控制 SURT。然而，许多有明显鼻窦或喉疾病的患者需要长期的全身治疗。虽然皮质激素通常是首选的初始药物，但已有数份关于细胞毒性药物和抗肿瘤坏死因子抗体有效性的报告。
