Benettini Giacomo, Bruschini Luca, Fiacchini Giacomo, Vianini Matteo, De Santi Silvia, Sparacino Lucrezia, Donati Valentina, Berrettini Stefano, De Vito Andrea
ENT Audiology and Phoniatric Unit, University Hospital of Pisa, Pisa, Italy.
Unit of Anatomic Pathology II, University Hospital of Pisa, Pisa, Italy.
Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(1):e2022010. doi: 10.36141/svdld.v39i1.11084. Epub 2022 Mar 31.
Sarcoidosis is a multisystemic inflammatory chronic disease characterized by the presence of noncaseating granulomas most frequently in lungs and in intrathoracic lymph nodes. The nasopharyngeal form is unusual and noncommon in the ENT practice.
In order to establish a correct knowledge about this rare disease, we report two different cases of nasopharyngeal sarcoidosis moreover all the available literature is reviewed.
A systematic literature review was made through PubMed databases, according to the PRISMA guidelines (1), combining the following key words: Nasopharyngeal, Rhinopharynx, Sarcoidosis, in publications between 1951 and 2020. In addition, we reported our personal experience on the disease by describing two clinical cases that occurred at our clinic in November 2018 and June 2019.
16 articles reported 27 cases of nasopharyngeal sarcoidosis. The number of males was 13 (48,2%) and the number of females was 14 (51,8%) with a mean age at the diagnosis of 35,28 ± 13.05 years old (range 5 - 64). In 16 (59,3%) cases nasopharyngeal sarcoidosis was associated with lungs and/or intrathoracic lymph nodes involvement; nasal obstruction was the most frequently reported symptom (51,8% of subjects).
Nasopharyngeal sarcoidosis can mimic several disorders of the upper airway respiratory tract and it must therefore be considered in the differential diagnosis. A biopsy of nonspecific lesions in the nasopharynx is advisable to permit several early diagnosis of upper airway respiratory tract disorders including sarcoidosis.
结节病是一种多系统炎症性慢性病，其特征是最常见于肺部和胸内淋巴结的非干酪样肉芽肿。鼻咽部结节病在耳鼻喉科临床实践中并不常见。
为了正确认识这种罕见疾病，我们报告了两例不同的鼻咽部结节病病例，并对所有现有文献进行了综述。
根据PRISMA指南（1），通过PubMed数据库进行系统的文献综述，结合以下关键词：鼻咽部、鼻咽喉、结节病，检索1951年至2020年期间发表的文献。此外，我们通过描述2018年11月和2019年6月在我们诊所发生的两例临床病例，报告了我们对该疾病的个人经验。
16篇文章报告了27例鼻咽部结节病。男性13例（48.2%），女性14例（51.8%），诊断时的平均年龄为35.28±13.05岁（范围5 - 64岁）。16例（59.3%）病例中，鼻咽部结节病与肺部和/或胸内淋巴结受累相关；鼻塞是最常报告的症状（51.8%的患者）。
鼻咽部结节病可模仿上呼吸道的几种疾病，因此在鉴别诊断中必须考虑到。建议对鼻咽部非特异性病变进行活检，以便早期诊断包括结节病在内的上呼吸道疾病。
