肝功能正常的乙肝病毒血清学阳性和血清学阴性患者的血清乙肝病毒DNA

Serum hepatitis B virus DNA in hepatitis B virus seropositive and seronegative patients with normal liver function.

作者信息

Pao C C, Yao D S, Lin C Y, Kao S M, Tsao K C, Sun C F, Liaw Y F

机构信息

Department of Biochemistry, Chang Gung Medical College, Taipei, Taiwan, Republic of China.

出版信息

Am J Clin Pathol. 1991 Apr;95(4):591-6. doi: 10.1093/ajcp/95.4.591.

DOI:10.1093/ajcp/95.4.591

PMID:2014786

Abstract

The presence of hepatitis type B virus (HBV) DNA in serum specimens from 926 apparently healthy people with normal liver functions was determined by polymerase chain reaction; 41.2% of people with positive results for HBV surface antigen (HBsAg) (94 of 228) and 95.2% of people with positive results for HBV e antigen (HBeAg) (60 of 63) were found to have positive results for serum HBV DNA. On the other hand, serum HBV DNA was found in 11.0% (77 of 698) of HBsAg-negative people and in 13% (69 of 530) of those who had positive results for serum antibodies directed against HBsAg. The results seem to suggest that HBV DNA can be found in a significant portion of apparently healthy people with normal liver function who are either seronegative for HBsAg or seropositive for antibodies directed against HBsAg.

摘要

采用聚合酶链反应检测了926例肝功能正常的表面健康者血清标本中乙型肝炎病毒（HBV）DNA的存在情况；结果发现，HBV表面抗原（HBsAg）检测呈阳性的人群中41.2%（228例中的94例）以及HBV e抗原（HBeAg）检测呈阳性的人群中95.2%（63例中的60例）血清HBV DNA检测呈阳性。另一方面，在HBsAg阴性的人群中，11.0%（698例中的77例）血清中检测到HBV DNA，在抗HBsAg血清抗体检测呈阳性的人群中，13%（530例中的69例）血清中检测到HBV DNA。结果似乎表明，在很大一部分肝功能正常的表面健康者中，无论是HBsAg血清学阴性还是抗HBsAg抗体血清学阳性，均可检测到HBV DNA。