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神经科学：缺乏抑制导致滥用。

Neuroscience: Lack of inhibition leads to abuse.

出版信息

Nature. 2010 Feb 11;463(7282):743-4. doi: 10.1038/463743a.

DOI:10.1038/463743a
PMID:20148025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6451657/
Abstract

Chronic drug use can lead to addiction, which is initiated by specific brain circuits. The mystery of how one class of drugs, the benzodiazepines, affects activity in this circuitry has finally been solved.

摘要

慢性药物使用会导致成瘾，而这是由特定的大脑回路引发的。一类药物，苯二氮䓬类药物，如何影响该回路活动的谜团终于被解开。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9717/6451657/ff3cd8db4edc/nihms-1018669-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9717/6451657/ff3cd8db4edc/nihms-1018669-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9717/6451657/ff3cd8db4edc/nihms-1018669-f0001.jpg

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本文引用的文献

1
Neural bases for addictive properties of benzodiazepines.苯二氮䓬类药物成瘾性的神经基础。
Nature. 2010 Feb 11;463(7282):769-74. doi: 10.1038/nature08758.
2
Strength through diversity.多元共生，强大之源。
Neuron. 2008 Nov 6;60(3):477-82. doi: 10.1016/j.neuron.2008.10.020.
3
The self-tuning neuron: synaptic scaling of excitatory synapses.自调节神经元：兴奋性突触的突触缩放
Cell. 2008 Oct 31;135(3):422-35. doi: 10.1016/j.cell.2008.10.008.
4
Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists.单次剂量苯二氮䓬类激动剂后腹侧被盖区多巴胺神经元中谷氨酸能传递的持久调节
Neuropsychopharmacology. 2009 Jan;34(2):290-8. doi: 10.1038/npp.2008.89. Epub 2008 Jun 18.
5
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.不同的GABAA受体亚型介导苯二氮䓬类药物在灵长类动物中的抗焦虑、成瘾相关及运动效应。
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):915-20. doi: 10.1073/pnas.0405621102. Epub 2005 Jan 11.
6
Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data.非苯二氮䓬类催眠药唑吡坦和佐匹克隆的滥用及依赖潜力：病例报告与流行病学数据综述
Addiction. 2003 Oct;98(10):1371-8. doi: 10.1046/j.1360-0443.2003.00491.x.
7
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.苯二氮䓬类药物的镇静而非抗焦虑特性由GABA(A)受体α1亚型介导。
Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761.
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Opioids excite dopamine neurons by hyperpolarization of local interneurons.阿片类药物通过使局部中间神经元超极化来兴奋多巴胺能神经元。
J Neurosci. 1992 Feb;12(2):483-8. doi: 10.1523/JNEUROSCI.12-02-00483.1992.