Nelson Sacha B, Turrigiano Gina G
Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454-9110, USA.
Neuron. 2008 Nov 6;60(3):477-82. doi: 10.1016/j.neuron.2008.10.020.
The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties.
哺乳动物大脑非凡的多功能性得益于多种多样的细胞可塑性机制。这些机制包括兴奋性和抑制性突触处的长时程增强和长时程抑制，以及各种内在和稳态可塑性机制。该领域的一个基本挑战是将我们对这些特定机制的详细了解整合为一幅连贯的图景，以阐明皮质回路中的可塑性如何调节网络特性。
