Turrigiano Gina G
Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA.
Cell. 2008 Oct 31;135(3):422-35. doi: 10.1016/j.cell.2008.10.008.
Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.
稳态突触缩放是一种突触可塑性形式，它可上调或下调神经元所有兴奋性突触的强度，以稳定放电。目前的证据表明，神经元通过一组钙依赖性传感器检测自身放电率的变化，这些传感器随后调节受体转运，以增加或减少突触部位谷氨酸受体的积累。其他机制可能允许通过平行通路感知局部或全网络范围的活动变化，从而产生一套嵌套的稳态机制，这些机制在不同的时间和空间尺度上起作用。
