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Lancet. 2009 Apr 18;373(9672):1352-63. doi: 10.1016/S0140-6736(09)60612-7. Epub 2009 Apr 8.
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First-line antiretroviral therapy in resource-limited settings: time to reconsider?资源有限环境下的一线抗逆转录病毒疗法:是时候重新考虑了吗?
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Comparison of CD4 cell count, viral load, and other markers for the prediction of mortality among HIV-1-infected Kenyan pregnant women.比较CD4细胞计数、病毒载量及其他标志物对肯尼亚感染HIV-1的孕妇死亡率的预测作用。
J Infect Dis. 2009 May 1;199(9):1292-300. doi: 10.1086/597617.
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Implementing family-focused HIV care and treatment: the first 2 years' experience of the mother-to-child transmission-plus program in Abidjan, Côte d'Ivoire.实施以家庭为中心的艾滋病毒护理和治疗:科特迪瓦阿比让母婴传播加项目的头两年经验。
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Low prevalence of detectable HIV plasma viremia in patients treated with antiretroviral therapy in Burkina Faso and Mali.布基纳法索和马里接受抗逆转录病毒治疗的患者中可检测到的艾滋病毒血浆病毒血症患病率较低。
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资源匮乏国家的抗逆转录病毒疗法:现实生活中我们需要什么?

Antiretroviral (ARV) Therapy in Resource Poor Countries: What do we Need in Real Life?

作者信息

Castelli Francesco, Pietra Virginio, Diallo Ismael, Schumacher Richard F, Simpore Jacques

机构信息

University of Brescia, Italy; CLIA - Network for International Fight against AIDS; President, Medicus Mundi Italy.

出版信息

Open AIDS J. 2010 Jan 19;4:28-32. doi: 10.2174/1874613601004020028.

DOI:10.2174/1874613601004020028
PMID:20148089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2817878/
Abstract

Significant progresses have been made in the last 5 years towards the ultimate goal to provide universal access to care for all HIV/AIDS patients needing antiretroviral treatment in resource-poor countries. However, many barriers are still to be overcome, including () cost of care for the individual, () stigma, () lack of qualified human resources and infrastructure, especially in the rural setting, () rescue drugs for failing patients and () pediatric formulations. Priority actions to be promoted if the fight against HIV/AIDS is to be successful include: (i) promoting access to care in the rural areas, (ii) strengthening of basic health infrastructures, (iii) waiving of users' fee to get ARV, (iv) a larger variety of drugs, with particular regard to fixed dose combination third line drugs and pediatric formulations, (v) local quality training and (vi) high quality basic and translational research. While the universal access to HIV care is crucial in developing countries, a strong emphasis on prevention should be maintained along.

摘要

在过去五年里,朝着为资源匮乏国家中所有需要抗逆转录病毒治疗的艾滋病毒/艾滋病患者提供普遍治疗这一最终目标取得了重大进展。然而,仍有许多障碍有待克服,包括(一)个人的护理费用,(二)耻辱感,(三)缺乏合格的人力资源和基础设施,尤其是在农村地区,(四)为治疗失败患者提供的抢救药物,以及(五)儿科配方。如果抗击艾滋病毒/艾滋病要取得成功,需要推动的优先行动包括:(一)促进农村地区获得治疗,(二)加强基本卫生基础设施,(三)免除抗逆转录病毒药物的使用者费用,(四)提供更多种类的药物,特别是固定剂量复方三线药物和儿科配方,(五)开展当地质量培训,以及(六)进行高质量的基础研究和转化研究。虽然在发展中国家普遍获得艾滋病毒治疗至关重要,但同时也应大力强调预防。