School of Biotechnology & Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chunchon, Kangwon-do 200-701, Korea.
Biotechnol Bioeng. 2010 Jun 1;106(2):295-302. doi: 10.1002/bit.22696.
beta-Cyclodextrin (beta-CD) hydrogel was prepared in a strong alkali condition using epichlorohydrin (EPI) as a cross-linker, where the molar ratios of EPI to beta-CD were 8:1, 10:1, and 15:1. In order to endow a pH sensitivity to the hydrogel, naphthaleneacetic acid (NAA) was loaded in the hydrogel by taking advantage of its hydrophobic interaction with the cavities of beta-CD. The releases of blue dextran (a water-soluble dye) from the hydrogels were promoted, as the pHs of the media increased. When the molar ratio of EPI to beta-CD was lower, the degrees of release were higher, and the pH dependency of the release became more prominent. In fact, the swelling ratio of the hydrogels having a lower molar ratio of EPI to beta-CD was higher. The higher swelling ratio would account for the higher degree of release and the marked pH sensitivity.
β-环糊精（β-CD）水凝胶在强碱条件下用表氯醇（EPI）作为交联剂制备，其中 EPI 与 β-CD 的摩尔比为 8:1、10:1 和 15:1。为了赋予水凝胶对 pH 值的敏感性，利用萘乙酸（NAA）与β-CD 空腔的疏水相互作用将其负载在水凝胶中。随着介质 pH 值的升高，蓝色葡聚糖（一种水溶性染料）从水凝胶中的释放得到促进。当 EPI 与 β-CD 的摩尔比较低时，释放程度较高，释放的 pH 值依赖性更加明显。事实上，EPI 与 β-CD 的摩尔比较低的水凝胶的溶胀率较高。较高的溶胀率将导致更高的释放程度和明显的 pH 值敏感性。
