College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
Carbohydr Polym. 2016 Jan 20;136:300-6. doi: 10.1016/j.carbpol.2015.08.096. Epub 2015 Sep 3.
2-Methylacrylic acid modified β-cyclodextrin was copolymerized with 2-methylacrylic acid and N,N'-methylene diacrylamide to fabricate dual pH and temperature responsive hydrogels for the controlled release of atorvastatin. The swelling behaviors, pH and temperature responsive atorvastatin release profiles of the hydrogels were investigated. The results indicated that the hydrogel prepared in DMSO exhibited the best swelling rate, which was 51 for 10 min and 252 for 16 h when immersed in medium of buffer solution with pH=8.06. The media with low (pH ≤ 3.84) and high (pH ≥ 10.34) pH values would reduce the swelling rate of hydrogels. The swelling of the hydrogel was increased with increasing temperature from 30 °C to 45 °C. Atorvastatin was loaded in the hydrogel for drug release investigation. The cumulative release rate of atorvastatin was as high as 90.5% in pH=8.06 buffer solution. The solubility of atorvastatin was improved from 0.13 to 1.2mg/mL in the hydrogel.
2-甲基丙烯酸改性的β-环糊精与 2-甲基丙烯酸和 N,N'-亚甲基双丙烯酰胺共聚，制备了双 pH 和温度响应水凝胶，用于控制阿托伐他汀的释放。研究了水凝胶的溶胀行为、pH 值和温度响应的阿托伐他汀释放特性。结果表明，在 DMSO 中制备的水凝胶具有最佳的溶胀率，在 pH=8.06 的缓冲溶液中浸泡 10 min 时为 51，16 h 时为 252。低 pH 值（pH≤3.84）和高 pH 值（pH≥10.34）的介质会降低水凝胶的溶胀率。水凝胶的溶胀随温度从 30°C 升高到 45°C 而增加。将阿托伐他汀载入水凝胶中进行药物释放研究。在 pH=8.06 的缓冲溶液中，阿托伐他汀的累积释放率高达 90.5%。在水凝胶中，阿托伐他汀的溶解度从 0.13mg/mL 提高到 1.2mg/mL。
Zotero 插件