Department of Hematology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia.
Clin Chem Lab Med. 2010 May;48(5):579-98. doi: 10.1515/CCLM.2010.121.
Defects in primary hemostasis typically lead to a bleeding diathesis and include several disorders, such as von Willebrand disease and various platelet function defects that may arise because of failure of membrane receptors, deficiencies in internal storage organelles, and/or signal transduction problems. The laboratory identification of a primary hemostasis defect including platelet function defects now involves a multi-step process. These processes begin with a full blood count to assess platelet count and size, progressing, if necessary, to platelet aggregation studies, and leading to further specific testing including flow cytometry, electron micro-scopy and/or genetic testing. This review outlines the sequential process of platelet function investigations, and discusses each of the essential components in some detail.
原发性止血缺陷通常导致出血倾向，包括几种疾病，如血管性血友病和各种血小板功能缺陷，可能由于膜受体功能障碍、内部储存细胞器缺陷和/或信号转导问题引起。包括血小板功能缺陷在内的原发性止血缺陷的实验室鉴定现在涉及一个多步骤的过程。这些过程首先从全血细胞计数开始，评估血小板计数和大小，如果需要，进行血小板聚集研究，然后进行进一步的特定测试，包括流式细胞术、电子显微镜和/或基因测试。这篇综述概述了血小板功能研究的顺序过程，并详细讨论了每个基本组成部分。
