Department of Laboratory Medicine, Dong-A University College of Medicine, 1,3-Ga, Dongdaesin-dong, Seo-gu, Busan 602-715, Republic of Korea.
Biomed Res Int. 2014;2014:456569. doi: 10.1155/2014/456569. Epub 2014 May 8.
The major goal of traditional platelet function tests has been to screen and diagnose patients who present with bleeding problems. However, as the central role of platelets implicated in the etiology of arterial thrombotic diseases such as myocardial infarction and stroke became widely known, platelet function tests are now being promoted to monitor the efficacy of antiplatelet drugs and also to potentially identify patients at increased risk of thrombosis. Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, are mediators of inflammation, and have immunomodulatory activity. As new potential biomarkers and technologies arrive at the horizon, platelet functions testing appears to take on a new aspect. This review article discusses currently available clinical application of platelet function tests, placing emphasis on essential characteristics.
传统血小板功能检测的主要目的一直是筛选和诊断有出血问题的患者。然而，随着血小板在心肌梗死和中风等动脉血栓性疾病发病机制中的核心作用被广泛认识，血小板功能检测现在也被用于监测抗血小板药物的疗效，并有可能识别血栓形成风险增加的患者。除止血和血栓形成外，越来越多的研究表明，血小板在细胞间通讯中起着不可或缺的作用，是炎症的介质，并具有免疫调节作用。随着新的潜在生物标志物和技术的出现，血小板功能检测似乎呈现出一个新的方面。本文讨论了血小板功能检测的现有临床应用，并强调了其重要特征。
