Department of Clinical Surgery, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
Obes Rev. 2010 Dec;11(12):863-74. doi: 10.1111/j.1467-789X.2010.00718.x.
Obesity is a well-established risk factor for the development and mortality from several cancers, including adenocarcinoma of the oesophagus, oesophago-gastric junction and colorectum. Despite a large body of epidemiological evidence describing this relationship, the mechanisms relating obesity and cancer are only starting to be uncovered. The altered secretion of metabolically active, pro-inflammatory adipocytokines from adipose tissue is believed to play a key role, and leptin is believed to be a key player in obesity-related carcinogenesis, as well as being the most extensively studied of the adipokines. In this literature review, we aim to examine the association between leptin and cancers of the gastro-intestinal tract. For each individual cancer, we examine and present the published data examining the role of leptin in both cell and animal models, the association between circulating leptin levels and cancer risk, and finally the expression of the leptin system in human gastro-intestinal tract tumours, in relation to tumour biology, stage and patient outcome.
肥胖是多种癌症（包括食管腺癌、食管胃交界处腺癌和结直肠癌）发生和死亡的一个既定危险因素。尽管有大量流行病学证据描述了这种关系，但肥胖与癌症之间的机制才刚刚开始被揭示。人们认为，脂肪组织中代谢活跃、促炎的脂肪细胞因子的异常分泌发挥着关键作用，而瘦素被认为是肥胖相关致癌作用的关键因素，也是研究最多的脂肪因子之一。在这篇文献综述中，我们旨在研究瘦素与胃肠道癌症之间的关系。对于每一种癌症，我们都检查和介绍了已发表的关于瘦素在细胞和动物模型中的作用、循环瘦素水平与癌症风险之间的关联以及人类胃肠道肿瘤中瘦素系统表达与肿瘤生物学、分期和患者预后的关系的研究数据。
