Ziylan Yusuf Ziya, Baltaci Abdulkerim Kasim, Mogulkoc Rasim
Department of Physiology, Istanbul Medical School, Istanbul University, Capa, Istanbul, Turkey.
Cell Biochem Funct. 2009 Mar;27(2):63-70. doi: 10.1002/cbf.1538.
Synthesized and released by the adipose tissue, leptin is the widely studied 167-amino acid hormonal protein product of the obesity gene. Originally leptin was defined in association with satiety and energy balance and claimed to be an anti-obesity factor that functioned via a feedback effect from adipocytes to hypothalamus. There is a growing body of evidence that emphasizes the importance of leptin in the regulation of food intake and body weight in animals and humans, alike. Other research findings point out that it plays a role in the regulation of the metabolism, sexual development, reproduction, hematopoiesis, immunity, gastrointestinal functions, sympathetic activation, and angiogenesis. The aim of this review is to evaluate the relation between leptin and the central nervous system (CNS).
瘦素由脂肪组织合成并释放，是肥胖基因产生的一种经过广泛研究的含167个氨基酸的激素蛋白产物。最初，瘦素被定义为与饱腹感和能量平衡相关，并被认为是一种通过脂肪细胞向下丘脑的反馈作用发挥功能的抗肥胖因子。越来越多的证据强调了瘦素在调节动物和人类食物摄入及体重方面的重要性。其他研究结果指出，它在新陈代谢、性发育、生殖、造血、免疫、胃肠功能、交感神经激活和血管生成的调节中发挥作用。本综述的目的是评估瘦素与中枢神经系统（CNS）之间的关系。
