Perlmann Eduardo, da Silva Enry Garcia, Guedes Pedro Mancini, Barros Paulo Sergio de Moraes
Laboratory of Investigation on Comparative Ophthalmology, School of Veterinary Medicine, University of São Paulo, São Paulo 05508 270, SP, Brazil.
Vet Ophthalmol. 2010 Jan;13(1):63-6. doi: 10.1111/j.1463-5224.2009.00760.x.
A 14-year-old spayed female domestic short-haired cat was presented for evaluation of a mass in the right eye. Ophthalmic examination revealed a blind right eye and presence of two distinct masses: a pink and a red-to-brown mass, the latter occupying most of the cornea and part of the conjunctiva. Exenteration was performed under general anesthesia, and the ocular tissues were processed routinely for histopathology. Upon microscopic examination, a malignant epithelial neoplasm and a benign vascular neoplasm were present in the cornea. The conjunctiva and the third eyelid were also affected. Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin. A diagnosis of squamous cell carcinoma (SCC) and hemangioma was made. The SCC was affecting the cornea, bulbar conjunctiva (lateral and inferior) and the base of the third eyelid, whereas the hemangioma was affecting the cornea and medial limbus. To the authors' knowledge, this is the first report of concomitant SCC and hemangioma affecting the ocular surface in a cat.
一只14岁已绝育的雌性家养短毛猫因右眼肿物前来评估。眼科检查发现右眼失明，有两个明显的肿物：一个粉色肿物和一个红棕色肿物，后者占据了大部分角膜和部分结膜。在全身麻醉下进行了眼球摘除术，并将眼组织常规处理用于组织病理学检查。显微镜检查显示角膜存在恶性上皮性肿瘤和良性血管性肿瘤。结膜和第三眼睑也受到影响。免疫组化显示，上皮性肿瘤细胞角蛋白阳性，波形蛋白阴性，内皮性肿瘤细胞角蛋白阴性，波形蛋白阳性。诊断为鳞状细胞癌（SCC）和血管瘤。SCC累及角膜、球结膜（外侧和下方）及第三眼睑基部，而血管瘤累及角膜和角膜缘内侧。据作者所知，这是首例猫眼表面同时发生SCC和血管瘤的报道。
