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CD56brightCD16- 自然杀伤细胞在接受体外受精的患者的卵巢卵泡液中积累。

CD56brightCD16- natural killer cells accumulate in the ovarian follicular fluid of patients undergoing in vitro fertilization.

机构信息

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada.

出版信息

Fertil Steril. 2010 Oct;94(5):1918-21. doi: 10.1016/j.fertnstert.2009.12.067. Epub 2010 Feb 10.

DOI:10.1016/j.fertnstert.2009.12.067
PMID:20149364
Abstract

CD56(bright)CD16(-) natural killer (NK) cells that express CXCR3 accumulate in the follicular fluid of patients with a good response to ovarian stimulation. It is conceivable that granulosa cells of good responders that express the chemokine CXCL10 recruit these NK cells to support follicular angiogenesis.

摘要

CD56(bright)CD16(-) 表达 CXCR3 的自然杀伤 (NK) 细胞在对卵巢刺激反应良好的患者的卵泡液中积聚。可以想象，表达趋化因子 CXCL10 的反应良好的颗粒细胞会招募这些 NK 细胞来支持卵泡血管生成。

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CD56brightCD16- natural killer cells accumulate in the ovarian follicular fluid of patients undergoing in vitro fertilization.CD56brightCD16- 自然杀伤细胞在接受体外受精的患者的卵巢卵泡液中积累。
Fertil Steril. 2010 Oct;94(5):1918-21. doi: 10.1016/j.fertnstert.2009.12.067. Epub 2010 Feb 10.
2
Maturation of human ovarian follicles is accompanied by a decrease in the CD56+CD16+ natural killer cell population.人类卵巢卵泡的成熟伴随着 CD56+CD16+自然杀伤细胞群体的减少。
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CD56brightCD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation.CD56brightCD16（-）自然杀伤细胞在银屑病皮肤中因趋化因子CXCL10和CCL5而积聚，并加剧皮肤炎症。
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An increase in the absolute count of CD56dimCD16+CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome.外周血中CD56dimCD16+CD69+自然杀伤细胞的绝对计数增加与体外受精治疗效果及妊娠结局较差相关。
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Timed sexual intercourse facilitates the recruitment of uterine CD56(bright) natural killer cells in women with infertility.定时性交有助于招募不孕女性子宫中的CD56（明亮型）自然杀伤细胞。
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The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells.CD56brightCD16-自然杀伤细胞的小亚群在与树突状细胞相互作用时，对细胞增殖和γ干扰素的产生均具有选择性作用。
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CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells.CD16 交联诱导外周 NK 细胞中 CD56 的表达增加和 IL-12 的产生。
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