Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany.
J Psychiatr Res. 2010 Oct;44(13):847-52. doi: 10.1016/j.jpsychires.2010.01.007. Epub 2010 Feb 10.
Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17alpha-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.
在边缘型人格障碍（BPD）患者中发现肥胖、内脏脂肪增加和葡萄糖代谢紊乱。这些情况通常与雄激素代谢紊乱有关。女性的雄激素升高与多囊卵巢（PCO）有关，可能对精神病理学有影响。因此，BPD 中怀疑存在更高的 PCO 患病率和升高的雄激素水平。在这项研究中，我们对 31 名 BPD 患者和 30 名健康对照者进行了超声 PCO 检查，并测量了他们的血清雄激素和相互作用激素水平。此外，还评估了游离睾酮（FT）血清水平对精神病理学的影响。BPD 患者的 PCO 患病率（30.4%）明显高于健康对照组（6.9%）。BPD 组的睾酮、FT、雄烯二酮（A）和 17α-羟孕酮（17-OHP）水平明显升高，与 BMI 无关。FT 血清水平与抑郁症状显著相关。总之，我们的数据表明 BPD 患者存在雄激素代谢紊乱。
