Husni Mariwan, Rizk Diaa E E, Alabdulla Nawal Saad, Zayed Aldana, Malas Hosni, Modahka Nourah Adbulaziz, Alqujan Sabeeka Jamal, Alansari Basma Khalid, Alhajri Shaika Ebrahim, Mahmood Nada, Jahrami Haitham
Department of Psychiatry, Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, 44001, Iraq.
Arch Womens Ment Health. 2025 May 6. doi: 10.1007/s00737-025-01589-8.
Polycystic ovarian syndrome (PCOS) is a common endocrine condition in women. Studies have shown that PCOS is associated with poor quality of life, anxiety, sadness, dissatisfaction with one's appearance, and sexual dysfunction.
This study was conducted to determine whether a strong psycho-pathological personality is related to PCOS and whether this personality is related to the hyperandrogenic state.
Anthropometric, metabolic, hormonal, clinical, and psychological characteristics were examined in 90 Bahraini women with PCOS. After confirming the diagnosis of PCOS via Rotterdam criteria, including ovarian ultrasound, each patient was evaluated via the following questionnaires: 1) the GAD-7 (General Anxiety Disorder-7) to measure the severity of anxiety; 2) the Patient Health Questionnaire-9 (PHQ-9) to confirm and measure the severity of depression; 3) the Barratt Impulsiveness Scale (BIS-11) to measure aggression; and 4) the McLean Screening Instrument to identify borderline personality disorders (MSI-BPDs). The study was approved by the Institutional Review Board.
Compared to controls, PCOS patients exhibited significantly higher rates of severe depression (8% vs. 0%, p < 0.001), severe anxiety (7% vs. 0%, p < 0.001), impulsivity (BIS-11: 39.43 ± 9.69 vs. 26.64 ± 2.92, p < 0.001), and borderline personality traits (McLean: 2.41 ± 2.44 vs. 1.2 ± 0.94, p < 0.001). Metabolic comorbidities, including obesity (BMI 28.88 vs. 20.27, p < 0.001) and hypothyroidism (48% vs. 0%, p < 0.001), were prevalent in PCOS. Hyperandrogenism correlated weakly with psychiatric outcomes (all p > 0.05).
Women with PCOS demonstrate markedly elevated psychiatric and medical burdens compared to healthy controls. While hyperandrogenism showed limited direct associations, metabolic dysfunction (e.g., obesity) may mediate psychiatric risk. These findings underscore the need for multidisciplinary care integrating psychological and endocrine management, particularly in populations where cultural norms exacerbate PCOS-related distress.
多囊卵巢综合征（PCOS）是女性常见的内分泌疾病。研究表明，PCOS与生活质量差、焦虑、悲伤、对外表不满以及性功能障碍有关。
本研究旨在确定强烈的心理病理人格是否与PCOS相关，以及这种人格是否与高雄激素状态相关。
对90名患有PCOS的巴林女性进行了人体测量、代谢、激素、临床和心理特征检查。通过鹿特丹标准（包括卵巢超声）确诊PCOS后，每位患者通过以下问卷进行评估：1）GAD-7（广泛性焦虑障碍-7）以测量焦虑的严重程度；2）患者健康问卷-9（PHQ-9）以确认和测量抑郁的严重程度；3）巴拉特冲动量表（BIS-11）以测量攻击性；4）麦克莱恩边缘性人格障碍筛查工具（MSI-BPD）以识别边缘性人格障碍。该研究获得了机构审查委员会的批准。
与对照组相比，PCOS患者出现严重抑郁（8%对0%，p<0.001）、严重焦虑（7%对0%，p<0.001）、冲动性（BIS-11：39.43±9.69对26.64±2.92，p<0.001）和边缘性人格特质（麦克莱恩量表：2.41±2.44对1.2±0.94，p<0.001）的比例显著更高。PCOS患者中代谢合并症普遍存在，包括肥胖（BMI 28.88对20.27，p<0.001）和甲状腺功能减退（48%对0%，p<0.001）。高雄激素血症与精神方面的结果相关性较弱（所有p>0.05）。
与健康对照组相比，PCOS女性的精神和医疗负担明显增加。虽然高雄激素血症的直接关联有限，但代谢功能障碍（如肥胖）可能介导精神风险。这些发现强调了综合心理和内分泌管理的多学科护理的必要性，特别是在文化规范加剧PCOS相关痛苦的人群中。
