细胞表面相关酶在β-内酰胺抗生素外膜通透性齐默尔曼-罗斯莱特试验中的作用。
Contribution of the cell-surface-associated enzyme in the Zimmermann-Rosselet assay of outer membrane permeability of beta-lactam antibiotics.
作者信息
Liu W, Nikaido H
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):177-9. doi: 10.1128/AAC.35.1.177.
Abstract
Analysis of beta-lactam hydrolysis by intact cells of several strains of enteric bacteria suggests that a significant fraction of beta-lactamase molecules is present at a location directly accessible for the substrates in the medium. We propose a method to correct for the error introduced by these "surface-exposed" enzymes in the Zimmermann-Rosselet assay of outer membrane permeability.
摘要
对几种肠道细菌完整细胞中β-内酰胺水解的分析表明，相当一部分β-内酰胺酶分子存在于培养基中底物可直接接触的位置。我们提出了一种方法，用于校正齐默尔曼-罗斯莱特外膜通透性测定中这些“表面暴露”酶所引入的误差。
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本文引用的文献
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Porin channels in Escherichia coli: studies with beta-lactams in intact cells.大肠杆菌中的孔蛋白通道：在完整细胞中使用β-内酰胺类药物的研究
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Sensitivity of Escherichia coli to various beta-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic beta-lactamases: a quantitative predictive treatment.大肠杆菌对各种β-内酰胺类药物的敏感性取决于外膜通透性和周质β-内酰胺酶降解作用之间的相互影响：一种定量预测性分析。
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