In vitro inactivation of aminoglycosides by sulbactam, other beta-lactams, and sulbactam-beta-lactam combinations.
作者信息
Fuchs P C, Stickel S, Anderson P H, Barry A L, Shilling S
机构信息
St. Vincent Hospital and Medical Center, Portland, Oregon 97225.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):182-4. doi: 10.1128/AAC.35.1.182.
Abstract
At clinically achievable levels (e.g., 25 micrograms/ml), sulbactam exerted no effect on aminoglycoside concentrations when incubated together in pooled serum at 37 degrees C for up to 24 h. Sulbactam alone and in combination with ampicillin or cefoperazone inactivated tobramycin, gentamicin, netilmicin, and amikacin in vitro when the sulbactam concentration was 200 to 225 micrograms/ml. At 75 micrograms/ml, sulbactam inactivated only tobramycin. Inactivation of tobramycin by high concentrations of sulbactam occurred even at -20 degrees C, but not at -70 degrees C, and was influenced by the serum matrix.
摘要
相似文献
1
In vitro inactivation of aminoglycosides by sulbactam, other beta-lactams, and sulbactam-beta-lactam combinations.
Antimicrob Agents Chemother. 1991 Jan;35(1):182-4. doi: 10.1128/AAC.35.1.182.
2
In vitro inactivation of aminoglycosides by apalcillin.
Antimicrob Agents Chemother. 1986 Feb;29(2):353-4. doi: 10.1128/AAC.29.2.353.
3
Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin.
J Pharmacol Exp Ther. 1981 May;217(2):345-9.
4
In vitro activity of beta-lactam drugs and sulbactam against Chlamydia trachomatis.
Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):371-3. doi: 10.1016/0732-8893(92)90027-q.
5
Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions.
Am J Med. 1986 Jun 30;80(6B):126-37. doi: 10.1016/0002-9343(86)90490-0.
6
[Mechanism of drug resistance of carbapenems-resistant Acinetobacter baumannii and the application of a combination of drugs in vitro].
Zhonghua Shao Shang Za Zhi. 2014 Apr;30(2):166-70.
7
8
Comparative aminoglycoside inactivation by beta-lactam antibiotics. Effects of a cephalosporin and six penicillins on five aminoglycosides.
J Antibiot (Tokyo). 1982 Jul;35(7):850-7. doi: 10.7164/antibiotics.35.850.
9
Tazobactam-piperacillin compared with sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam-cefoperazone, and piperacillin for activity against beta-lactamase-producing bacteria isolated from patients with complicated urinary tract infections.
J Chemother. 1997 Apr;9(2):89-94. doi: 10.1179/joc.1997.9.2.89.
10
Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin.
Antimicrob Agents Chemother. 1991 Sep;35(9):1875-8. doi: 10.1128/AAC.35.9.1875.
引用本文的文献
1
Pharmacokinetic parameters of netilmicin and protective effect of piperacillin regarding nephrotoxicity caused by netilmicin.
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):143-7. doi: 10.1007/BF03189330.
2
Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin.
Antimicrob Agents Chemother. 1991 Sep;35(9):1875-8. doi: 10.1128/AAC.35.9.1875.
本文引用的文献
1
Inactivation of aminoglycosides by penicillins.
J Antimicrob Chemother. 1981 Jul;8 Suppl A:27-36. doi: 10.1093/jac/8.suppl_a.27.
2
Inactivation of amikacin and gentamicin by carbenicillin in patients with end-stage renal failure.
Antimicrob Agents Chemother. 1982 Sep;22(3):376-9. doi: 10.1128/AAC.22.3.376.
3
Animal model distinguishing in vitro from in vivo carbenicillin-aminoglycoside interactions.
Antimicrob Agents Chemother. 1980 Oct;18(4):604-9. doi: 10.1128/AAC.18.4.604.
4
Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease.
Antimicrob Agents Chemother. 1982 Feb;21(2):268-73. doi: 10.1128/AAC.21.2.268.
5
Comparative study of the ability of four aminoglycoside assay techniques to detect the inactivation of aminoglycosides by beta-lactam antibiotics.
Diagn Microbiol Infect Dis. 1984 Apr;2(2):93-100. doi: 10.1016/0732-8893(84)90003-8.
6
Laboratory and clinical conditions for gentamicin inactivation by carbenicillin.
Arch Intern Med. 1972 Dec;130(6):887-91.
7
Therapeutic implications of interaction of gentamicin and penicillins.
Lancet. 1971 Sep 11;2(7724):575-8. doi: 10.1016/s0140-6736(71)92152-0.
8
Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin.
Lancet. 1971 Feb 6;1(7693):261-4. doi: 10.1016/s0140-6736(71)91001-4.
9
In vitro interaction of aminoglycosides with beta-lactam penicillins.
Antimicrob Agents Chemother. 1985 Aug;28(2):274-81. doi: 10.1128/AAC.28.2.274.
10
Comparative aminoglycoside inactivation by potassium clavulanate.
J Antimicrob Chemother. 1986 May;17(5):682-4. doi: 10.1093/jac/17.5.682.
Zotero 插件