舒巴坦、其他β-内酰胺类药物以及舒巴坦-β-内酰胺类药物组合对氨基糖苷类药物的体外灭活作用。
In vitro inactivation of aminoglycosides by sulbactam, other beta-lactams, and sulbactam-beta-lactam combinations.
作者信息
Fuchs P C, Stickel S, Anderson P H, Barry A L, Shilling S
机构信息
St. Vincent Hospital and Medical Center, Portland, Oregon 97225.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):182-4. doi: 10.1128/AAC.35.1.182.
Abstract
At clinically achievable levels (e.g., 25 micrograms/ml), sulbactam exerted no effect on aminoglycoside concentrations when incubated together in pooled serum at 37 degrees C for up to 24 h. Sulbactam alone and in combination with ampicillin or cefoperazone inactivated tobramycin, gentamicin, netilmicin, and amikacin in vitro when the sulbactam concentration was 200 to 225 micrograms/ml. At 75 micrograms/ml, sulbactam inactivated only tobramycin. Inactivation of tobramycin by high concentrations of sulbactam occurred even at -20 degrees C, but not at -70 degrees C, and was influenced by the serum matrix.
摘要
在临床可达到的水平（例如25微克/毫升）下，当舒巴坦与氨基糖苷类药物在37℃的混合血清中共同孵育长达24小时时，对氨基糖苷类药物浓度没有影响。当舒巴坦浓度为200至225微克/毫升时，单独的舒巴坦以及与氨苄西林或头孢哌酮联合使用时，在体外可使妥布霉素、庆大霉素、奈替米星和阿米卡星失活。在75微克/毫升时，舒巴坦仅使妥布霉素失活。高浓度的舒巴坦即使在-20℃也会使妥布霉素失活，但在-70℃不会，并且受到血清基质的影响。
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